Molecular Approaches and Modern Clinical Strategies for the Management of Helicobacter pylori Infection in Japan

Suzuki, Hidekazu; Nishizawa, Toshihiro; Tsugawa, Hitoshi; Hibi, Toshifumi

doi:10.2302/kjm.2012-0001-re

Cited by 11 publications

(9 citation statements)

References 63 publications

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“…Helicobacter pylori (H. pylori) infection is one of the most prevalent infectious diseases worldwide, with 40 % to 50 % of the global human population estimated to be infected [1]. H. pylori is associated with development of atrophic gastritis and gastric cancer [2][3][4][5], and eradication of H. pylori infection has been reported as an effective strategy for treating atrophic gastritis and peptic ulcer and preventing gastric cancer [6][7][8][9]. There-fore, it is important to estimate H. pylori infection status [10].…”

Section: Introductionmentioning

confidence: 99%

Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection

Toyoshima

Nishizawa

Sakitani³

et al. 2020

Endosc Int Open

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Background and study aims Helicobacter pylori-associated nodular gastritis, which is associated with follicular lymphoid hyperplasia, is mainly recognized in the antrum. However, we have also observed nodularity-like appearance in the cardia. This study aimed to investigate the clinical signiﬁcance of cardiac nodularity-like appearance in H. pylori-associated gastritis. Patients and methods Patients who underwent esophagogastroduodenoscopy and were evaluated for H. pylori infection for the ﬁrst time were enrolled. A nodularity-like appearance in the cardia was defined as a miliary nodular appearance or scattered appearances of small circular whitish coloration. H. pylori infection was diagnosed according to serum anti-H. pylori antibody and the urea breath test or histology. Accuracy of the H. pylori infection diagnoses based on nodularity-like appearance were assessed. Results Among 265 patients, 42 patients (15.8 %) were diagnosed as positive for H. pylori. Cardiac nodularity-like appearance and antral nodularity were recognized in 25 and 15 patients, respectively. In accuracy of predicting H. pylori by cardiac nodularity-like appearance, specificity was 0.996, sensitivity was 0.571, positive predictive value was 0.960, negative predictive value was 0.925, and accuracy was 0.928. The sensitivity of cardiac nodularity-like appearance was significantly higher than that of antral nodularity (P = 0.0284). Conclusions Cardiac nodularity-like appearance had a high accuracy rate for H. pylori infection diagnosis. Cardiac nodularity-like appearance was found more frequently than antral nodularity.

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Section: Introductionmentioning

confidence: 99%

Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection

Toyoshima

Nishizawa

Sakitani³

et al. 2020

Endosc Int Open

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“…13 Diagnostic methods of H pylori infection include 13 C-urea breath tests (UBTs), measuring serum levels of anti-H pylori antibodies, stool antigen tests, rapid urease tests, culture and pathology. 14,15 UBT is regarded as the gold standard because of its higher degree of accuracy. Serum anti-H pylori antibody tests are easy and inexpensive, with commercial test kits yielding accuracies of 89% to 95%, sensitivities of 88% to 96%, and specificities of 86% to 96%.…”

Section: Introductionmentioning

confidence: 99%

“…Diagnostic methods of H pylori infection include 13 C‐urea breath tests (UBTs), measuring serum levels of anti‐ H pylori antibodies, stool antigen tests, rapid urease tests, culture and pathology 14 , 15 . UBT is regarded as the gold standard because of its higher degree of accuracy.…”

Section: Introductionmentioning

confidence: 99%

A combination of serum anti‐Helicobacter pylori antibody titer and Kyoto classification score could provide a more accurate diagnosis of H pylori

et al. 2019

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Background We previously showed that the endoscopic Kyoto classification for gastritis could predict Helicobacter pylori infection in individuals with a high negative titer of serum anti- H pylori antibodies. This study evaluated H pylori infection and the Kyoto classification score in patients with a low negative titer (<3 U/ml), high negative titer (3–9.9 U/ml), low positive titer (10–49.9 U/ml), and high positive titer (≥50 U/ml). Methods Serum antibody levels, Kyoto classification score and histology were investigated in 870 individuals with no history of H pylori -eradication therapy. Urea breath tests (UBTs) were additionally conducted for patients with a low negative titer and a Kyoto score ≥1 or an antibody titer ≥10 U/ml and a Kyoto score of 0 or 1. UBTs and/or histological studies were conducted for participants with a high negative titer. Results False diagnoses based on anti- H pylori antibody titers were observed in 0.3% of the low-negative-titer group, 11.7% of the high-negative-titer group, 18.9% of the low-positive-titer group and 2.2% of the high-positive-titer group. Surprisingly, false diagnoses based on antibody titers were noted in 63.2% of patients with a low positive titer and a Kyoto score of 0 and in 62.5% of patients with a high negative titer and a Kyoto score ≥2, respectively. Conclusions Endoscopic findings could predict false diagnoses determined using serum antibody titers.

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“…Diagnostic methods for H. pylori infection with endoscopy include the culture test, microscopic test, and rapid urease test. The tests without endoscopy include the urea breath test (UBT), blood H. pylori antibody test, and faeces H. pylori antigen test [4,5]. According to the Japanese Society for Helicobacter Research guidelines [6], UBT is the most accurate among the tests, and its sensitivity and speci city are 98% [7].…”

Section: Introductionmentioning

confidence: 99%

Latex Agglutination Turbidimetric Immunoassay Versus Enzyme-Linked Immunosorbent Assay for Helicobacter pylori: An Observational Study.

Tokai¹,

Fujisaki²,

Ishizuka³

et al. 2020

Preprint

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Background: Helicobacter pylori antibody levels in the blood are currently measured using an enzyme-linked immunosorbent assay (ELISA). In April 2016, FUJIFILM Wako Pure Chemical Corporation launched the “L-type Wako Helicobacter pylori antibody J” test, which is based on the latex agglutination turbidimetric immunoassay. In this study, we investigated the usefulness of the Wako test. Methods: We measured H. pylori antibody levels using both ELISA and Wako tests in 180 patients who underwent esophagogastroduodenoscopy at our hospital between September 2017 and February 2019. Ninety patients had H. pylori infections. We calculated the diagnostic accuracy, sensitivity, and specificity of each test and the concordance rate between the two tests. If the lower limits of 90% confidence intervals (CI) for each diagnostic validity exceeded the 85% threshold, the usefulness of the diagnostic test was confirmed. Results: Diagnostic accuracy, sensitivity, and specificity were 94.4% (90% CI; 90.8–97.0%), 94.4% (90% CI; 88.7–97.8%), and 94.4% (90% CI; 88.7–97.8%), respectively, using the Wako test, and 94.4% (90% CI; 90.8–97.0%), 88.9% (90% CI; 81.9–93.8%), and 100% (90% CI; 96.0–100%), respectively, using ELISA. The concordance rate between the two tests was high (κ = 0.8444). Conclusions: We confirmed the usefulness of the Wako test, especially when screening for H. pylori infection, due to its high sensitivity.Trial registration: We retrospectively registered the data of this study.

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Molecular Approaches and Modern Clinical Strategies for the Management of Helicobacter pylori Infection in Japan

Cited by 11 publications

References 63 publications

Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection

Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection

A combination of serum anti‐Helicobacter pylori antibody titer and Kyoto classification score could provide a more accurate diagnosis of H pylori

Latex Agglutination Turbidimetric Immunoassay Versus Enzyme-Linked Immunosorbent Assay for Helicobacter pylori: An Observational Study.

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