Molecular approach to identifying route of transmission of tuberculosis in the community

Genewein, A.; Telenti, Amalio; Bernasconi, C.; Schopfer, K; Bodmer, Thomas; Mordasini, Carlo; Weiss, Stanley H.; Maurer, A. M.; Rieder, Hans L.

doi:10.1016/0140-6736(93)92698-s

Cited by 177 publications

(107 citation statements)

References 20 publications

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“…B. das 16S rRNA-Gen oder 23SrRNA-Gen), über [17]. Andere Studien konzentrieren sich auf das Problem der Ansteckung in Gefängnissen [18] oder in bestimmten Risikogruppen (Drogenabhängige, Obdachlose, Alkoholiker [19,20] …”

Section: Identifizierung Von Mykobakterienunclassified

Stellenwert der Polymeraseketten-Reaktion (PCR) und anderer Amplifikationsverfahren in der Diagnostik der Tuberkulose

Pfyffer

2004

Pneumologie

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ªThe ability of the PCR procedure to amplify a target DNA segment in genomic DNA raises the possibility that its use may extend beyond that of prenatal diagnosis to other areas of molecular biology.º Saiki et al. 1985. AbstractWorldwide, tuberculosis (TB) remains one of the leading infectious diseases, accounting for nearly 3 million deaths and more than 8 million new cases annually. Among them are 3.2 % multidrug-resistant strains of Mycobacterium tuberculosis. In the control of the spread of TB clinical mycobacteriology laboratories play an essential role providing the clinicians with timely detection, isolation, identification, and drug susceptibility testing results for M. tuberculosis. In the past twenty years numerous molecular techniques have been introduced to comply with the obvious needs for a reliable and rapid diagnosis of the disease. Nucleic acid amplification-based assays, in particular, the polymerase chain reaction (PCR), allow (i) direct detection of M. tuberculosis complex in clinical specimens; (ii) identification of mycobacteria; (iii) detection of resistance of M. tuberculosis to antimicrobial agents; and (iv) DNA typing to answer questions such as reactivation of disease or exogenous reinfection, and to track transmission and internal laboratory contaminations.

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Section: Identifizierung Von Mykobakterienunclassified

Stellenwert der Polymeraseketten-Reaktion (PCR) und anderer Amplifikationsverfahren in der Diagnostik der Tuberkulose

Pfyffer

2004

Pneumologie

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“…Esto demuestra el valor de la técnica en revelar fuentes de transmisión no reconocidas anteriormente. Otros estudios que utilizan la estrategia de tipaje molecular han identificado rutas de transmisión en la comunidad con hallazgos similares (33)(34)(35)(36)(37). El estudio de Berna es el que ha tenido los hallazgos más dramáticos: un solo paciente contribuyó con 13% de los casos de la región; sólo a través del RFLP se pudo poner en evidencia la relación epidemiológica de estos casos (33).…”

Section: Aplicaciones Del Rflp En Colombiaunclassified

Epidemiología molecular por la técnica RFLP en tuberculosis: una nueva herramienta para el control de una antigua infección

Gómez

Portaels

1996

biomedica

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“…A study using IS6110-RFLP recently showed that extensive transmission of TB is taking place in Europe in the same social settings as those reported in the USA (Genewein et al 1993); more than one quarter of the patients in Berne (Switzerland) were linked to other patients and mainly associated with outbreaks within families or with drug addicts and homeless persons. Importantly, transmission was not limited to these high risk groups as there was a "spill over" to the general population.…”

Section: Applications Of Molecular Strain Typing As An Additional Toomentioning

confidence: 99%

The Changing Face of the Epidemiology of Tuberculosis due to Molecular Strain Typing: A Review

Suffys¹,

Araujo²,

Degrave³

1997

Mem. Inst. Oswaldo Cruz

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Molecular approach to identifying route of transmission of tuberculosis in the community

Cited by 177 publications

References 20 publications

Stellenwert der Polymeraseketten-Reaktion (PCR) und anderer Amplifikationsverfahren in der Diagnostik der Tuberkulose

Stellenwert der Polymeraseketten-Reaktion (PCR) und anderer Amplifikationsverfahren in der Diagnostik der Tuberkulose

Epidemiología molecular por la técnica RFLP en tuberculosis: una nueva herramienta para el control de una antigua infección

The Changing Face of the Epidemiology of Tuberculosis due to Molecular Strain Typing: A Review

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