Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions

Fischer, Inbar; Barak, Boaz

doi:10.3390/biom10091247

Cited by 25 publications

(20 citation statements)

References 141 publications

(204 reference statements)

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“…Hypoxia occurs in a variety of neurological conditions such as traumatic brain injury, Alzheimer's disease, and stroke, and is known to be responsible for some of their symptoms. In hyperbaric oxygen therapy, subjects are placed in a chamber filled with 100% oxygen gas at a pressure of 1 atm or higher, and it is mainly used to treat hypoxia-related symptoms [7]. Oxygen is used to produce ATP by oxidative phosphorylation and electron transfer systems.…”

Section: Introductionmentioning

confidence: 99%

Multi-Omic Meta-Analysis of Transcriptomes and the Bibliome Uncovers Novel Hypoxia-Inducible Genes

Ono

Bono

2021

Biomedicines

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Hypoxia is a condition in which cells, tissues, or organisms are deprived of sufficient oxygen supply. Aerobic organisms have a hypoxic response system, represented by hypoxia-inducible factor 1-α (HIF1A), to adapt to this condition. Due to publication bias, there has been little focus on genes other than well-known signature hypoxia-inducible genes. Therefore, in this study, we performed a meta-analysis to identify novel hypoxia-inducible genes. We searched publicly available transcriptome databases to obtain hypoxia-related experimental data, retrieved the metadata, and manually curated it. We selected the genes that are differentially expressed by hypoxic stimulation, and evaluated their relevance in hypoxia by performing enrichment analyses. Next, we performed a bibliometric analysis using gene2pubmed data to examine genes that have not been well studied in relation to hypoxia. Gene2pubmed data provides information about the relationship between genes and publications. We calculated and evaluated the number of reports and similarity coefficients of each gene to HIF1A, which is a representative gene in hypoxia studies. In this data-driven study, we report that several genes that were not known to be associated with hypoxia, including the G protein-coupled receptor 146 gene, are upregulated by hypoxic stimulation.

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Section: Introductionmentioning

confidence: 99%

Multi-Omic Meta-Analysis of Transcriptomes and the Bibliome Uncovers Novel Hypoxia-Inducible Genes

Ono

Bono

2021

Biomedicines

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“…Since lncRNA-H19 expression was found to be tightly correlated with hypoxic inducement in previous study [35], we then investigated whether OGD-induced lncRNA-H19 elevation was altered in the presence of HBO treatment and its effect on NLRP3-dependent pyroptosis signaling in NSCs. HBO is a powerful therapy that boosts oxygen diffusion in hypoxic/ischemic tissue and alleviates secondary injury through targeting noncoding RNA [13,14,40]. It has been reported that HBO treatment induces lncRNA-MALAT1 to target miR-92a/KLF2 for angiogenesis after myocardial infarction [21].…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, whether and how lncRNA-H19 contributes to NSC pyroptosis and affects neurogenesis following OGD has never been investigated. NOD-like receptor protein 3 (NLRP3) inflammasome assembly is essential for the downstream Caspase-1 activation and gasdermin D (GSDMD) pore formation in the canonical pyroptosis signaling [13,14]. Online bioinformatic analysis and screening demonstrate that lncRNA-H19 is predicted to bind microRNA-423-5p (miR-423-5p) directly, and miR-423-5p is predicted to bind the 3′UTR of NLRP3.…”

Section: Introductionmentioning

confidence: 99%

“…Hyperbaric oxygen (HBO), a practical approach to ameliorate hypoxic state, has been shown to promote neurogenesis and facilitate neurological function recovery after stroke [13,14]. HBO treatment not only enhances the viability and survival of NSCs but also enhances NSC proliferation and differentiation into neurons after ischemic injury [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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HBO Alleviates Neural Stem Cell Pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 Axis and Improves Neurogenesis after Oxygen Glucose Deprivation

Feng

Tian

et al. 2022

Oxidative Medicine and Cellular Longevity

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Due to the limited neurogenesis capacity, there has been a big challenge in better recovery from neurological dysfunction caused by stroke for a long time. Neural stem cell (NSC) programmed death is one of the unfavorable factors for neural regeneration after stroke. The types of death such as apoptosis and necroptosis have been deeply investigated while the pyroptosis of NSCs is not quite understood. Although it is well accepted that hyperbaric oxygen (HBO) alleviates the oxygen-glucose deprivation (OGD) injury after stroke and reduces programmed death of NSCs, whether NSC pyroptosis is involved in this process is still unknown. Therefore, this study is aimed at studying the potential effect of HBO treatment on NSC pyroptosis following OGD exposure, as well as its influence on NSC proliferation and differentiation in vitro. The results revealed that OGD increased NOD-like receptor protein 3 (NLRP3) expression to induce the pyroptotic death of NSCs, which was rescued by HBO treatment. And the upregulated lncRNA-H19 functioned as a molecular sponge of miR-423-5p to target NLRP3 for NSC pyroptosis following OGD. Most importantly, it was confirmed that HBO exerted protection of NSCs against pyroptosis by inhibiting lncRNA-H19/miR-423-5p/NLRP3 axis. Moreover, HBO restraint of lncRNA-H19-associated pyroptosis benefited the proliferation and neuronal differentiation of NSCs. It was concluded that HBO attenuated NSC pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 axis and enhanced neurogenesis following OGD. The findings provide new insight into NSC programmed death and enlighten therapeutic strategy after stroke.

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“…Hypoxia occurs in a variety of neurological conditions such as traumatic brain injury, Alzheimer's disease, and stroke, and is known to be responsible for some of their symptoms. In hyperbaric oxygen therapy, subjects are placed in a chamber filled with 100% oxygen gas at a pressure of 1 atm or higher, and is mainly used to treat hypoxia-related symptoms [7]. Oxygen is used to produce ATP by oxidative phosphorylation and electron transfer systems.…”

Section: Introductionmentioning

confidence: 99%

Multi-omic meta-analysis of transcriptomes and the bibliome uncovers novel hypoxia-inducible genes

Ono

Bono

2021

Preprint

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Hypoxia is a condition in which cells, tissues, or organisms are deprived of sufficient oxygen supply. Aerobic organisms have the hypoxic response system, represented by hypoxia-inducible factor 1-α (HIF1A), to avoid this condition. Because of publication bias, the genes other than well-known signature hypoxia-stimulating genes may not be focused. Therefore, in this study, we performed meta-analysis to identify novel hypoxia-responsive genes. We searched publicly available transcriptome databases to obtain hypoxia-related experimental data, retrieved the metadata, and manually curated it. We selected the genes that are differentially expressed by hypoxic stimulation, and evaluated their relevance in hypoxia by performing enrichment analyses. We then calculated the number of reports and similarity coefficient of each gene for HIF1A (surrogate for hypoxia) using gene2pubmed that provides information about the relationship between gene and publication. Enrichment analysis confirmed that the selected genes were related to hypoxic stimulation, as expected. We then performed gene2pubmed analysis to investigate the genes that had not been fully studied under hypoxia. In this data-driven study, we report that the G protein-coupled receptor 146 gene is upregulated by hypoxic stimulation.

show abstract

Molecular and Therapeutic Aspects of Hyperbaric Oxygen Therapy in Neurological Conditions

Cited by 25 publications

References 141 publications

Multi-Omic Meta-Analysis of Transcriptomes and the Bibliome Uncovers Novel Hypoxia-Inducible Genes

Multi-Omic Meta-Analysis of Transcriptomes and the Bibliome Uncovers Novel Hypoxia-Inducible Genes

HBO Alleviates Neural Stem Cell Pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 Axis and Improves Neurogenesis after Oxygen Glucose Deprivation

Multi-omic meta-analysis of transcriptomes and the bibliome uncovers novel hypoxia-inducible genes

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