Molecular and physiological insights into plague transmission, virulence and etiology

Zhou, Dongsheng; Han, Yanping; Yang, Ruifu

doi:10.1016/j.micinf.2005.06.006

Cited by 69 publications

(48 citation statements)

References 129 publications

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“…Furthermore, the bacteria within macrophages can be trafficked to the local draining lymph node [28]. Between four and five days after infection, the number of Y. pestis increases rapidly in vivo, and the bacteria can escape from macrophages into the extracellular compartment with phagocytosis resistance and it seems that the components PhoP/PhoQ can have an important role for intracellular Y. pestis survival in macrophages [29].…”

Section: Acquirement Of Phagocytosis Resistancementioning

confidence: 99%

Role of immune response in Yersinia pestis infection

Amedei

Niccolai

Marino

et al. 2011

J Infect Dev Ctries

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Yersinia pestis (Y. Pestis) is an infamous pathogen causing plague pandemics throughout history and is a selected agent of bioterrorism threatening public health. Y. pestis was first isolated by Alexandre Yersin in 1894 in Hong Kong and in the following years from all continents. Plague is enzootic in different rodents and their fleas in Africa, North and South America, and Asia, including the Middle/Far East and ex-USSR countries. Comprehending the multifaceted interaction between Y. pestis and the host immune system will enable us to design more effective vaccines. Innate immune response and both components (humoral and cellular) of adaptive immune response contribute to host defense against Y. pestis infection, but the bacterium possesses different mechanisms to counteract the immune response. The review aims to analyze the role of immune response versus Yersinia pestis infection and to highlight the various stratagems adopted by Y. pestis to escape the immunological defenses.

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Section: Acquirement Of Phagocytosis Resistancementioning

confidence: 99%

Role of immune response in Yersinia pestis infection

Amedei

Niccolai

Marino

et al. 2011

J Infect Dev Ctries

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“…It is one of several virulent microorganisms known to have changed human civilization pathways and has attracted great attention due to its bioterrorism potential (1)(2)(3). Naturally occurring and genetically engineered antibiotic-resistant Y. pestis strains increase our concerns about the threat of its misuse as a biological weapon or bioterrorism agent.…”

mentioning

confidence: 99%

Outer Membrane Proteins Ail and OmpF of Yersinia pestis Are Involved in the Adsorption of T7-Related Bacteriophage Yep-phi

Zhao

Cui

Yan

et al. 2013

J Virol

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Yep-phi is a T7-related bacteriophage specific to Yersinia pestis, and it is routinely used in the identification of Y. pestis in China. Yep-phi infects Y. pestis grown at both 20°C and 37°C. It is inactive in other Yersinia species irrespective of the growth temperature. Based on phage adsorption, phage plaque formation, affinity chromatography, and Western blot assays, the outer membrane proteins of Y. pestis Ail and OmpF were identified to be involved, in addition to the rough lipopolysaccharide, in the adsorption of Yep-phi. The phage tail fiber protein specifically interacts with Ail and OmpF proteins, and residues 518N, 519N, and 523S of the phage tail fiber protein are essential for the interaction with OmpF, whereas residues 518N, 519N, 522C, and 523S are essential for the interaction with Ail. This is the first report to demonstrate that membrane-bound proteins are involved in the adsorption of a T7-related bacteriophage. The observations highlight the importance of the tail fiber protein in the evolution and function of various complex phage systems and provide insights into phage-bacterium interactions.

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“…Y. pestis infection has a high mortality rate and a short incubation before mortality. [1] There is no widely available and effective vaccine for Y. pestis and multi-drug resistant strains are emerging. Y. pestis is a recognized biothreat agent based on the wide distribution of the bacteria in research laboratories around the world and on the knowledge that methods exist to produce and aerosolize large amounts of bacteria.…”

Section: Motivationmentioning

confidence: 99%