Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population

Abstract

1. Electrolyte imbalance is a common complication in cancer that mainly involves sodium, potassium, and calcium alterations. 2. If the individual at risk is not monitored and hydrated, it leads to severe complications.3. Hydration status assessed in various indices; plasma, sweat, saliva, urine, interstitial fluid, and skin interface have been widely used, but no unified (de)hydration monitoring technologies exist for different populations.

WNK1 in Malignant Behaviors: A Potential Target for Cancer?

“…We recently showed that Kir2.1 and Kir2.3 channels harbor an alternative SPAK/OSR1 binding motifs (RxFxV), leading to their plasma membrane localization (Taylor et al, 2018). Alterations of electrolyte homeostasis are frequently observed in cancer patients (Miltiadous et al, 2008;Rosner and Dalkin, 2014;Li et al, 2020;Bennet et al, 2021). These ion transporters and channels have frequently been implicated in the regulation of migration and invasion (Cuddapah and Sontheimer, 2011;Schwab and Stock, 2014;Stock and Schwab, 2015;Martial, 2016).…”

“…We recently showed that Kir2.1 and Kir2.3 channels harbor an alternative SPAK/OSR1 binding motifs (RxFxV), leading to their plasma membrane localization ( Taylor et al, 2018 ). Alterations of electrolyte homeostasis are frequently observed in cancer patients ( Miltiadous et al, 2008 ; Rosner and Dalkin, 2014 ; Li et al, 2020 ; Bennet et al, 2021 ).…”

Forward single‐cell sequencing into clinical application: Understanding of ageing and rejuvenation from clinical observation to single‐cell solution

“…The isomers of the same lipid element can be different across ages of patients with lung cancer, for example, isomers of lysophosphatidylserine 15:1 and 20:3 elevated in ages < 60, while 15:0 and 20:1‐2 in ages between 60–70. Of multiple factors, ageing can change the balance between the electrolyte and water levels in lifespan 16 …”

Fast Synthesis of Au Nanoparticles on Metal–Phenolic Network for Sweat SERS Analysis

“…Ions such as Na + , Cl − , and K + can also be flown out with perspiration, thereby affecting the pH value of sweat [ 10 , 11 ]. Excessive exercise may lead to excessive loss of mineral components in the body, causing electrolyte imbalance and endangering health [ 12 ]. The use of real-time portable photoelectric sensors helps to provide athletes with scientific sports data, formulate better training programs, and avoid training risk [ 13 ].…”