Abstract:Four decades after L-dopa was introduced as a therapy for Parkinson's disease, it is still the gold standard for Parkinson's pharmacological treatment because no new drug has been discovered. This is due to the ambiguity regarding the molecular mechanisms responsible for the degeneration of dopaminergic neurons containing neuromelanin in the substantia nigra, which induces the motor symptoms of Parkinson's disease. The question is to identify the mechanisms underlying the neurodegenerative process of Parkinson… Show more
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