Molecular and immunological characterization of wheat allergens responsible for Baker's asthma

Immunological and clinical evaluation of Triticum aestivum aeroallergens in asthmatic patients

“…Despite of huge beneficial to mankind, protein fractions such as gluten, albumin, globulin, alpha amylase/trypsin, lipid transfer protein, peroxidases, tri a 36, tri a 14, C3a, glupearl 19S, serine proteinase inhibitor, thioredoxin and gliadin are present in wheat and has been reported to be acted as aeroallergen in allergic Asthma or food allergen. They can be exercise triggered allergic reaction or contact allergen like in contact dermatitis 16,17,[27][28][29] . Most of the Pakistani population came in contact with specific aero-allergen including mites, cockroach and dog epithelial during inhalation 15 and wheat was also found to be one of the major aero as well as food allergen among egg, milk, beef, chicken, mutton, fish, corn, lentils, rice, soya, peanut and banana 5 .…”

“…Wheat allergy may be IgE or immune complex or cell mediated 14 . IgE mediated wheat hypersensitivity can be diagnosed by skin prick test, oral challenge, Enzyme-linked immunosorbent assay or ImmunoCAP test 15,16 . It was estimated that IgE, against 47 kDa and 20 kDa of wheat protein, present in serum of patients.…”