“…10 Depending on the detection method, geographic area, and tumor type, the infection rates of HPV in PSCC range from 20% to 80%. 1,[11][12][13] A close association between high-risk HPV (hrHPV) infection and p16 INK4a overexpression has repeatedly been reported for several tumors, such as squamous cell carcinoma (SCC) of the head and neck region and cervical cancer. 14 However, limited data are available regarding p16 INK4a immunodetection in PSCC, its relationship with HPV detection, and its prognostic significance.…”