Molecular and functional characterization of reversible‐sunitinib‐tolerance state in human renal cell carcinoma
Angela Zaccagnino,
Bozhena Vynnytska‐Myronovska,
Michael Stöckle
et al.
Abstract:Therapy failure with the tyrosine kinase inhibitor (TKI) sunitinib remains a great challenge in metastatic renal cell carcinoma (mRCC). Growing evidence indicates that the tumour subpopulation can enter a transient, non‐mutagenic drug‐tolerant state to endure the treatment underlying the minimal residual disease and tumour relapse. Drug tolerance to sunitinib remains largely unexplored in RCC. Here, we show that sunitinib‐tolerant 786‐O/S and Caki‐2/S cells are induced by prolonged drug treatment showing reduc… Show more
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