Molecular and functional changes in neutrophilic granulocytes induced by nicotine: a systematic review and critical evaluation
Theresa-Charlotte Brembach,
Robert Sabat,
Katrin Witte
et al.
Abstract:BackgroundOver 1.1 billion people smoke worldwide. The alkaloid nicotine is a prominent and addictive component of tobacco. In addition to tumors and cardiovascular disorders, tobacco consumption is associated with a variety of chronic-inflammatory diseases. Although neutrophilic granulocytes (neutrophils) play a role in the pathogenesis of many of these diseases, the impact of nicotine on neutrophils has not been systematically reviewed so far.ObjectivesThe aim of this systematic review was to evaluate the di… Show more
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