Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation
Rémi-Xavier Coux,
Agnès Dubois,
Almira Chervova
et al.
Abstract:Pioneer transcription factors (TF) bind nucleosome-embedded DNA motifs to activate new regulatory elements and promote differentiation. However, the complexity, binding dependencies and temporal effects of their action remain unclear. Here, we dissect how the pioneer TF GATA6 triggers Primitive Endoderm (PrE) differentiation from pluripotent cells. We show that transient GATA6 binding exploits accessible regions to decommission active enhancers and promote pluripotency gene silencing. Simultaneously, GATA6 tar… Show more
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