Molecular and electrophysiological characterizations of fGluR3α, an ionotropic glutamate receptor subunit of a teleost fish

Chang, Hao‐Ming; Wu, Yi-Mi; Chang, Y. C.; Hsu, Yu-Chung; Hsu, Hsiu-Ya; Chen, Yu‐Chia; Chow, Wei-Yuan

doi:10.1016/s0169-328x(98)00086-2

Cited by 7 publications

(1 citation statement)

References 44 publications

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“…These values from eight different species spanning diverse taxonomic groups of mammals, birds, and fish are remarkably similar and are all within one order of magnitude (Table 3). This is not surprising given that glutamate receptors are highly conserved across vertebrate taxa (Chang et al, 1998;Schioth and Fredriksson, 2005;Appelbaum et al, 2009). Based solely on these metrics, one could incorrectly conclude that mammal, bird, and fish species are similarly affected by DA during toxic Pseudo-nitzschia blooms.…”

Section: Susceptibility To Da Via Injection Exposure In Mammals Birdmentioning

confidence: 99%

Domoic acid and fish behavior: A review

2012

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Section: Susceptibility To Da Via Injection Exposure In Mammals Birdmentioning

confidence: 99%

Domoic acid and fish behavior: A review

2012

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Structure of Ionotropic Glutamate Receptors

Hollmann¹

1999

Ionotropic Glutamate Receptors in the CNS

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The Mutually Exclusive Flip and Flop Exons of AMPA Receptor Genes Were Derived from an Intragenic Duplication in the Vertebrate Lineage

Chen¹,

Lin²,

Tzeng³

et al. 2006

J Mol Evol

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The incomplete correlation between the organismal complexities and the number of genes among eukaryotic organisms can be partially explained by multiple protein products of a gene created by alternative splicing. One type of alternative splicing involves alternative selection of mutually exclusive exons and creates protein products with substitution of one segment of the amino acid sequence for another. To elucidate the evolution of the mutually exclusive 115-bp exons, designated flip and flop, of vertebrate AMPA receptor genes, the gene structures of chordate (tunicate, cephalochordate, and vertebrate) and protostome (Drosophila and Caenorhabditis elegans) AMPA receptor subunits were compared. Phylogenetic analysis supports that the vertebrate flip and flop exons evolved from a common sequence. Flip and flop exons exist in all vertebrate AMPA receptor genes but only one 115-bp exon is present in the genes of tunicates and cephalochordates, suggesting that the exon duplication event occurred at the ancestral vertebrate AMPA receptor gene after the separation of vertebrates from primitive chordates. The structures of animal AMPA receptor genes also suggest that an intron insertion to separate the primordial flip/flop exon from the M4-coding exon occurred before the exon duplication event and probably at the chordate lineage.

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Molecular and electrophysiological characterizations of fGluR3α, an ionotropic glutamate receptor subunit of a teleost fish

Cited by 7 publications

References 44 publications

Domoic acid and fish behavior: A review

Domoic acid and fish behavior: A review

Structure of Ionotropic Glutamate Receptors

The Mutually Exclusive Flip and Flop Exons of AMPA Receptor Genes Were Derived from an Intragenic Duplication in the Vertebrate Lineage

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