Molecular and Clinicopathological Features of Gastrointestinal Stromal Tumors in Vietnamese Patients

Ngo, Quoc Dat; Pham, Quoc Thang; Phan, Dang Anh Thu; Hoang, Anh Vu; Hua, Thi Ngoc Ha; Nguyen, Su

doi:10.4132/jptm.2019.08.27

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…1). A total of 20 studies that fulfilled the inclusion criteria were finally included in the analysis (15,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). The NOS was used to verify the quality of the evidence.…”

Section: Resultsmentioning

confidence: 99%

Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis

Li¹,

Wang²,

Chen³

et al. 2022

Oncol Lett

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Overexpression of Ki67 is observed in tumor cells, and it has been suggested to be a marker for cancer prognosis. However, the relationship between Ki67 expression and the risk of recurrence of gastrointestinal stromal tumors (GISTs) remains poorly defined. In the present study, a meta-analysis was used to examine the associations between Ki67 levels and GIST recurrence. Studies reporting GIST and Ki67 were found by searching Cochrane Library, PubMed and Embase until October 14, 2021. The Newcastle-Ottawa Scale (NOS) was used to verify the quality of the evidence. Totally, 1682 patient cases were included. The odds ratio (OR) estimates and 95% confidence interval (CI) for each publication were determined by a fixed-effects (Mantel-Haenszel) model. A total of 20 studies that fulfilled the inclusion criteria were finally included in the analysis. The average score of quality evaluation was 6.4 points according to NOS. It was found that Ki67 levels were significantly higher in the NIH L group compared with the NIH VL group (OR: 0.51; 95% CI: 0.26-0.99; P= 0.04; P heterogeneity= 0.44). There was also greater Ki67 overexpression in the NIH I group compared with the NIH L group (OR: 0.45, 95% CI: 0.31-0.65; P<0.0001; P heterogeneity= 0.32), while Ki67 levels were greater in the NIH H group than in the NIH I group (OR: 0.20; 95% CI: 0.15-0.28; P<0.00001; P heterogeneity= 0.56). In conclusion, Ki67 overexpression may be a useful marker of the risk of recurrent GIST transformation.

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Section: Resultsmentioning

confidence: 99%

Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis

Li¹,

Wang²,

Chen³

et al. 2022

Oncol Lett

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Endoscopic ultrasound‐guided fine‐needle aspiration cytology in the diagnosis of the gastrointestinal stromal tumor of the stomach

Val‐Bernal

Yllera

Moris

et al. 2020

Diagnostic Cytopathology

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BackgroundThis study aims to evaluate the usefulness of endoscopic ultrasound‐guided fine‐needle aspiration cytology (EUS‐FNAC) in the diagnosis of the gastric gastrointestinal stromal tumor (GIST).MethodsWe retrospectively investigated the efficacy and accuracy of EUS‐FNAC in the diagnosis of gastric GIST. Cytological smears and cytoblock sections including immunohistochemistry and mutational studies from patients diagnosed as gastric GISTs were retrieved.ResultsThirty patients (mean age 68.8 years, range 32‐88 years, Male:Female 1:1.7) were diagnosed by cytological and cytoblock study to have GIST. The size of tumors ranged from 1.6 to 25 cm (mean 6.0 cm). 7 (23%) cases were incidentally discovered. Location was: gastric body 13 (43.3%), fundus 8 (26.7%), antrum 7 (23.3%), cardia 2 (6.7%). The study of removed tumors was correlated with the cytological findings. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 75%, 100%, 100%, 46%, and 96%. There were no false‐positive cases. The preoperative risk assessment of 27 cases with cytoblock were: none 3 (11.1%), very low 8 (29.6%), low 12 (44.4%), high 3 (11.1%), insufficient clinical data 1 (3.7%). The follow‐up varied from 2 to 120 months (mean 46.7 months). Only 1 patient of the high‐risk group died. The most frequent mutations found were those of c‐KIT in exon 11.ConclusionsPathological diagnosis was based on a combination of cytological, histopathological, and immunohistochemical features. EUS‐FNAC is a reliable, accurate, and safe method for the diagnosis of GIST. The cytoblock allows tumor risk classification and mutational study of the cases.

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Molecular and Clinicopathological Features of Gastrointestinal Stromal Tumors in Vietnamese Patients

Cited by 2 publications

References 33 publications

Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis

Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis

Endoscopic ultrasound‐guided fine‐needle aspiration cytology in the diagnosis of the gastrointestinal stromal tumor of the stomach

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