“…ROS-1 rearrangement occurs at a breakpoint in the ROS gene at the 5′ end of exons 32, 34, 35, or 36, or introns 31 or 33 [ 14 , 34 ]. The most frequently seen fusion partners ( Table 1 ) are CD74 (38–54%), EZR (13%–24%), SDC4 (9–13%), and SLC34A2 (5–10%) [ 34 , 35 ]. However, improved DNA- and RNA-sequencing techniques have enabled identification of numerous fusion partners, including CCCKC6 , TFG, SLMAP, MYO5C, FIG, LIMA1, CLTC, GOPC, ZZCCHC8, CEP72, MLL3, KDELR2, LRIG3, MSN, MPRIP, WNK1, SLC6A17, TMEM106B, FAM135B, TPM3, and TDP52L1 [ 36 ].…”