Molecular and Cellular Mechanism of Action of Chrysotile Asbestos in MRC5 Cell Line
Assiya Kussainova,
Olga Bulgakova,
Akmaral Aripova
et al.
Abstract:Asbestos is a known carcinogen; however, the influence of chrysotile asbestos on the development of tumor-related diseases remains a subject of intense debate within the scientific community. To analyze the effect of asbestos, we conducted a study using the MRC5 cell line. We were able to demonstrate that chrysotile asbestos stimulated the production of reactive oxygen species (ROS), leading to cell death and DNA damage in the MRC5 cell line, using various techniques such as ROS measurement, comet assay, MTT a… Show more
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