Molecular and Cellular Biology of Mammalian Progesterone Receptors

Savouret, J.-F.; Misrahi, Micheline; Loosfelt, Hugues; Atger, Michel; Bailly, Alain; Perrot‐Applanat, Martine; Hai, M. T. Vu; Guiochon‐Mantel, Anne; Jolivet, André; Lorenzo, Frédéric; Logeat, Frédérique; Pichon, M.; Milgröm, Edwin; Bouchard, Philippe

doi:10.1016/b978-0-12-571145-6.50007-8

Cited by 20 publications

(20 citation statements)

References 127 publications

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“…The classical genomic mechanism of progesterone action involves passage of progesterone through the plasma membranes of target cells, where they can bind to PR. The activated progesterone-PR complex then moves into the nucleus and binds to response elements on progesterone responsive genes to regulate their transcriptional activity (Robinson et al 2001;Savouret et al 1989). Besides the genomic mechanism, progesterone can exhibit its influence on vertebrates via non-genomic mechanisms in the cytoplasm (Bramley 2003).…”

Section: Discussionmentioning

confidence: 98%

The identification and distribution of progesterone receptors in the brain and thoracic ganglion in the mud crab Scylla paramamosain (Crustacea: Decapoda: Brachyura)

Huang

Song

et al. 2010

Invert Neurosci

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The existence of progesterone receptors (PR) in the Scylla paramamosain (mud crab) was studied using immunological techniques. By Western blotting, PR with an apparent molecular weight of 70 kDa is identified in both the brain and the thoracic ganglion. By immunohistochemistry, PR immunoreactive neurons are detected mainly in the protocerebrum, the subesophageal ganglion and the leg ganglion. PR immunoreactivity is localized mainly in the nuclei of these neurons, while only a few neurons show such activities in their cytoplasm. Our results provide evidence that progesterone modulates the neuroendocrine system mainly via nucleus receptors.

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Section: Discussionmentioning

confidence: 98%

The identification and distribution of progesterone receptors in the brain and thoracic ganglion in the mud crab Scylla paramamosain (Crustacea: Decapoda: Brachyura)

Huang

Song

et al. 2010

Invert Neurosci

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“…An alternative possibility could be that P 4 acts though a glucocorticoid receptor, which is present within the rat ovary [32] and can be activated or antagonized by P 4 and RU-486, respectively [33]. Recent studies have shown that P 4 down-regulates the expression of 20␣-hydrosteroid dehydrogenase within rat luteal cells and that this action is mediated through the glucocorticoid receptor [32].…”

Section: Discussionmentioning

confidence: 98%

Progesterone Maintains Large Rat Granulosa Cell Viability Indirectly by Stimulating Small Granulosa Cells to Synthesize Basic Fibroblast Growth Factor1

Peluso

Pappalardo

1999

Biology of Reproduction

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Ovarian follicles are composed of small and large granulosa cells (GCs). Since progesterone (P4) inhibits large GCs from undergoing apoptosis, studies were designed to determine whether both sizes of GCs bind P4. These studies revealed that fluorescein isothiocyanate-BSA-P4 bound only to the surface membranes of small GCs. This binding was steroid-specific and inhibited by an antibody directed against the ligand-binding domain of the nuclear P4 receptor (PR). In addition, a cell-impermeable derivative of P4, BSA-conjugated P4, was as effective as P4 in preventing apoptosis. Quantitative in situ hybridization studies showed that P4 increased the relative amount of basic fibroblast growth factor (bFGF) mRNA expressed per cell as well as the percentage of small GCs that expressed bFGF. To determine whether the anti-apoptotic action of P4 was mediated by bFGF, GCs were cultured in control medium supplemented with either P4, a neutralizing antibody to bFGF, or both P4 and the bFGF antibody. The results from this study demonstrated that P4 suppressed apoptosis and that this effect was attenuated in presence of the bFGF antibody. Basic FGF also prevented GC apoptosis, and its action was not influenced by either the PR antagonist (RU-486), an inhibitor of P4 synthesis (aminoglutethimide), or a PR antibody. Finally, FGF receptors were detected on both small and large GCs. Collectively, these data support the hypothesis that P4 acts through a putative membrane receptor on small GCs to stimulate the synthesis of bFGF. Basic FGF then activates its receptors within large GCs, and this initiates a signal transduction pathway that maintains large GC viability.

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“…In the past 3 decades, further insight into the actions of steroid hormones has been gained and there have been several comprehensive reviews on this subject (Hansen etal., 1988;Sheridan etal., 1988;Savouret, 1989;Martin et ai, 1990;Funder, 1991;O'Malley, 1991;Wilson, 1991). The current hypothesis of sex steroid hormone action (see Figure 5) begins with the secretion of the hormones into the bloodstream, where they circulate, principally bound (approximately 98%) to plasma proteins.…”

Section: Mechanism Of Action Of Sex Steroid Hormonesmentioning

confidence: 97%

Sex Steroid Hormones and Cell Dynamics in the Periodontium

Mariotti

1994

Critical Reviews in Oral Biology & Medicine

182

248

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The biological changes that occur in tissues of the periodontium during puberty, the menstrual cycle, pregnancy, menopause, and oral contraceptive use have heightened interest in the relationship between sex steroid hormones and periodontal health. These clinical observations coupled with tissue specificity of hormone localization, identification of hormone receptors, as well as the metabolism of hormones have strongly suggested that periodontal tissues are targets for androgens, estrogens, and progestins. The etiologies of periodontal endocrinopathies are diverse; nonetheless, periodontal pathologies may be a consequence of the actions and interactions of sex steroid hormones on specific cells found in the periodontium.

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Molecular and Cellular Biology of Mammalian Progesterone Receptors

Cited by 20 publications

References 127 publications

The identification and distribution of progesterone receptors in the brain and thoracic ganglion in the mud crab Scylla paramamosain (Crustacea: Decapoda: Brachyura)

The identification and distribution of progesterone receptors in the brain and thoracic ganglion in the mud crab Scylla paramamosain (Crustacea: Decapoda: Brachyura)

Progesterone Maintains Large Rat Granulosa Cell Viability Indirectly by Stimulating Small Granulosa Cells to Synthesize Basic Fibroblast Growth Factor1

Sex Steroid Hormones and Cell Dynamics in the Periodontium

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