Molecular and biochemical evidence on the protective effects of quercetin in isoproterenol‐induced acute myocardial injury in rats

Kumar, Mukesh; Kasala, Eshvendar Reddy; Bodduluru, Lakshmi Narendra; Kumar, Vikas; Lahkar, Mangala

doi:10.1002/jbt.21832

Cited by 45 publications

(35 citation statements)

References 42 publications

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“…A wide range of evidence supports the cardioprotective effects of QUE relying mainly on its antioxidant properties [ 49 , 50 ]. The antioxidant properties of QUE have been attributed to its ability to protect mitochondria and induce biogenesis by activating the Nrf2 signaling pathway [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Quercetin Prevents Diastolic Dysfunction Induced by a High‐Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats

Castillo

Herrera

Gonzaléz‐Candia

et al. 2018

Oxidative Medicine and Cellular Longevity

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Alterations in cardiac energy metabolism play a key role in the pathogenesis of diabetic cardiomyopathy. Hypercholesterolemia associated with bioenergetic impairment and oxidative stress has not been well characterized in the cardiac function under glycemic control deficiency conditions. This work aimed to determine the cardioprotective effects of quercetin (QUE) against the damage induced by a high-cholesterol (HC) diet in hyperglycemic rats, addressing intracellular antioxidant mechanisms and bioenergetics. Quercetin reduced HC-induced alterations in the lipid profile and glycemia in rats. In addition, QUE attenuated cardiac diastolic dysfunction (increased E:A ratio), prevented cardiac cholesterol accumulation, and reduced the increase in HC-induced myocyte density. Moreover, QUE reduced HC-induced oxidative stress by preventing the decrease in GSH/GSSG ratio, Nrf2 nuclear translocation, HO-1 expression, and antioxidant enzymatic activity. Quercetin also counteracted HC-induced bioenergetic impairment, preventing a reduction in ATP levels and alterations in PGC-1α, UCP2, and PPARγ expression. In conclusion, the mechanisms that support the cardioprotective effect of QUE in rats with HC might be mediated by the upregulation of antioxidant mechanisms and improved bioenergetics on the heart. Targeting bioenergetics with QUE can be used as a pharmacological approach to modulate structural and functional changes of the heart under hypercholesterolemic and hyperglycemic conditions.

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Section: Discussionmentioning

confidence: 99%

Quercetin Prevents Diastolic Dysfunction Induced by a High‐Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats

Castillo

Herrera

Gonzaléz‐Candia

et al. 2018

Oxidative Medicine and Cellular Longevity

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show abstract

“…The effect of quercetin has also been confirmed in two other studies where it suppresses TNF-α while reducing pro-inflammatory cytokine IL-6 levels. However, it also increases anti-inflammatory cytokine IL-10 levels [165]. In another animal study, quercetin has protected isolated hearts against I/R injury by inhibiting the inflammatory markers TNF-α and IL-1β [166].…”

Section: Effects Of Quercetinmentioning

confidence: 96%

Protective Effects of Polyphenols against Ischemia/Reperfusion Injury

Cebová

Pecháňová

2020

Molecules

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Myocardial infarction (MI) is a leading cause of morbidity and mortality across the world. It manifests as an imbalance between blood demand and blood delivery in the myocardium, which leads to cardiac ischemia and myocardial necrosis. While it is not easy to identify the first pathogenic cause of MI, the consequences are characterized by ischemia, chronic inflammation, and tissue degeneration. A poor MI prognosis is associated with extensive cardiac remodeling. A loss of viable cardiomyocytes is replaced with fibrosis, which reduces heart contractility and heart function. Recent advances have given rise to the concept of natural polyphenols. These bioactive compounds have been studied for their pharmacological properties and have proven successful in the treatment of cardiovascular diseases. Studies have focused on their various bioactivities, such as their antioxidant and anti-inflammatory effects and free radical scavenging. In this review, we summarized the effects and benefits of polyphenols on the cardiovascular injury, particularly on the treatment of myocardial infarction in animal and human studies.

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“…Two weeks of QCT pretreatment (50 mg/kg) of rats with isoproterenol-induced myocardial infarction induced cardioprotective effects manifested by significantly attenuated oxidative stress, inflammation, as well as protected heart architecture. These effects of QCT were associated with downregulation of the expression of calpain [86]. QCT was shown beneficial also in Duchenne muscular dystrophy, a juvenile musculoskeletal genetic disease associated with progressive cardiac pathology.…”

Section: In Vivo Cardioprotection Afforded By Qct and Qct-rich Plantsmentioning

confidence: 98%

Potential Implications of Quercetin and its Derivatives in Cardioprotection

Ferenczyová

Kaločayová

Barteková

2020

IJMS

102

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Quercetin (QCT) is a natural polyphenolic compound enriched in human food, mainly in vegetables, fruits and berries. QCT and its main derivatives, such as rhamnetin, rutin, hyperoside, etc., have been documented to possess many beneficial effects in the human body including their positive effects in the cardiovascular system. However, clinical implications of QCT and its derivatives are still rare. In the current paper we provide a complex picture of the most recent knowledge on the effects of QCT and its derivatives in different types of cardiac injury, mainly in ischemia-reperfusion (I/R) injury of the heart, but also in other pathologies such as anthracycline-induced cardiotoxicity or oxidative stress-induced cardiac injury, documented in in vitro and ex vivo, as well as in in vivo experimental models of cardiac injury. Moreover, we focus on cardiac effects of QCT in presence of metabolic comorbidities in addition to cardiovascular disease (CVD). Finally, we provide a short summary of clinical studies focused on cardiac effects of QCT. In general, it seems that QCT and its metabolites exert strong cardioprotective effects in a wide range of experimental models of cardiac injury, likely via their antioxidant, anti-inflammatory and molecular pathways-modulating properties; however, ageing and presence of lifestyle-related comorbidities may confound their beneficial effects in heart disease. On the other hand, due to very limited number of clinical trials focused on cardiac effects of QCT and its derivatives, clinical data are inconclusive. Thus, additional well-designed human studies including a high enough number of patients testing different concentrations of QCT are needed to reveal real therapeutic potential of QCT in CVD. Finally, several negative or controversial effects of QCT in the heart have been reported, and this should be also taken into consideration in QCT-based approaches aimed to treat CVD in humans.

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Molecular and biochemical evidence on the protective effects of quercetin in isoproterenol‐induced acute myocardial injury in rats

Cited by 45 publications

References 42 publications

Quercetin Prevents Diastolic Dysfunction Induced by a High‐Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats

Quercetin Prevents Diastolic Dysfunction Induced by a High‐Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats

Protective Effects of Polyphenols against Ischemia/Reperfusion Injury

Potential Implications of Quercetin and its Derivatives in Cardioprotection

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