Molecular and anatomic considerations in the pathogenesis of breast cancer

Wazer, David E.; Band, Vimla

doi:10.1002/(sici)1520-6823(1999)7:1<1::aid-roi1>3.0.co;2-i

Cited by 10 publications

(3 citation statements)

References 49 publications

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“…Many studies relating molecular factors to breast cancer risk rely on end-point tumor analyses that make it challenging to dissociate tumor-initiating changes from byproducts of tumorigenesis (17,18). It is estimated that an individual cell requires the accumulation of 5 to 10 genetic or epigenetic events before neoplastic transformation occurs (19) and then another 10 to 15 years (in humans) for a neoplastically transformed cell to progress to a clinically detectable tumor (20). Due to the significant delays between cancer-predisposing events, cancer initiation, and cancer detection, the factors involved in cancer risk need to be assessed long before cancer diagnosis is possible.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Experiences Differentially Influence Mammary Gland Morphology, Estrogen Receptor α Protein Levels, and Carcinogenesis in BALB/c Mice

Boyd

Salleh

Humber

et al. 2010

Cancer Prevention Research

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Prevention of breast cancer can be achieved with a better understanding of the factors contributing to normal breast development. Because the breast develops postnatally, alterations in the development and lifetime activity of the neuroendocrine system may set up an environment that increases cancer risk. The present study examined how two neonatal experiences over the first 3 weeks of life influence normal and malignant mammary gland development in female BALB/c mice. Following puberty, both brief (15 minutes) and prolonged (4 hours) daily maternal separations of newborn mice accelerated mammary gland development relative to nonseparated mice. Despite similar mammary gland morphologies between mice exposed to these two neonatal separation experiences, only mice exposed to prolonged maternal separation bouts showed a higher incidence and faster onset of mammary tumorigenesis following adulthood carcinogen [7,12-dimethylbenz(a)anthracene] administration. Molecular analysis of estrogen receptor α (ERα) and p53, two proteins that have been implicated in breast cancer, revealed that for mice exposed to prolonged neonatal maternal separation bouts, mammary gland ERα protein levels were upregulated in a transcription-independent manner. On the other hand, p53 expression in mammary glands of adult mice was not differentially influenced by neonatal experiences. Our findings show that chronic, moderate psychosocial stress during the neonatal period increases the expression of ERα protein and promotes mammary tumorigenesis in adulthood. Cancer Prev Res; 3(11); 1398-408. ©2010 AACR.

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Section: Introductionmentioning

confidence: 99%

Neonatal Experiences Differentially Influence Mammary Gland Morphology, Estrogen Receptor α Protein Levels, and Carcinogenesis in BALB/c Mice

Boyd

Salleh

Humber

et al. 2010

Cancer Prevention Research

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“…In order to induce cells passing through unlimited proliferation, different kinds of methods have been explored. Carcinogenic agents ( 17 ), radiation ( 18 ) and even viral oncogenes ( 9 , 19 , 20 ) have been used to immortalize cells. However, carcinogenic agents like benzoapyrene (BaP) had tumorigenicity in nude mice, limiting its application ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Establishment of a sheep immortalization cell line for generating and amplifying Orf virus recombinants

Sun

Zhao²,

Lu³

et al. 2022

Front. Vet. Sci.

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Orf virus (ORFV) causes highly contagious vesiculoulcerative pustular and skin lesions in ruminants like sheep. Developing ORFV-based recombinant vaccine is a potential way to combat Orf disease. Although ORFV could propagate in some kinds of primary cells, the proliferative capacity of primary cells is limited. Therefore, establishing immortalized stable cell line is an effective and affordable way for the production of live ORFV vaccine. In the present study, we introduced a telomerase reverse transcriptase (TERT) gene-expressing cassette into primary ovine fetal turbinate (OFTu) cells, then selected and expanded the cells, which was considered as immortalized OFTu cell line. Our results showed that TERT introduction has successfully expended the lifespan of OFTu cell line over 80 passages, without changing the cellular morphology, affecting chromosomes karyotype and inducing the cellular tumorigenic ability. Immortalized OFTu cell line-derived ORFV has caused similar levels of cytopathic effects (CPE), viral titers and viral particles when compared with the ORFV from primary OFTu cell. Importantly, immortalized OFTu cell line was suitable for generating gene-modified ORFV recombinant through homologous recombination, and for the amplification of ORFV recombinant. In summary, an immortalized OFTu cell line was established and characterized, which could be a powerful tool for preparing ORFV recombinant vaccines.

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“…It is estimated that about 40-60% breast cancer patients with early stage disease will undergo radiation treatment (36)(37)(38), However, development of radiation-induced secondary malignancy after successful radiotherapy of a prior cancer has been well documented. It is generally accepted among radiation oncologists that for most patients this is an unavoidable complication (39). However, for a specific population of patients, such as BRCA2 or BRCAl germline mutation carriers, the risk of radiation induced breast cancer warrants further investigation.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility of BRCA2 Heterozygous Normal Mammary Epithelial Cells to Radiation Induced Transformation

Gao¹

2002

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Molecular and anatomic considerations in the pathogenesis of breast cancer

Cited by 10 publications

References 49 publications

Neonatal Experiences Differentially Influence Mammary Gland Morphology, Estrogen Receptor α Protein Levels, and Carcinogenesis in BALB/c Mice

Neonatal Experiences Differentially Influence Mammary Gland Morphology, Estrogen Receptor α Protein Levels, and Carcinogenesis in BALB/c Mice

Establishment of a sheep immortalization cell line for generating and amplifying Orf virus recombinants

Susceptibility of BRCA2 Heterozygous Normal Mammary Epithelial Cells to Radiation Induced Transformation

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