Molecular analysis of the extracellular microenvironment: from form to function
Jade K. Macdonald,
Anand S. Mehta,
Richard R. Drake
et al.
Abstract:The extracellular matrix (ECM) proteome represents an important component of the tissue microenvironment that controls chemical flux and induces cell signaling through encoded structure. The analysis of the ECM represents an analytical challenge through high levels of post‐translational modifications, protease‐resistant structures, and crosslinked, insoluble proteins. This review provides a comprehensive overview of the analytical challenges involved in addressing the complexities of spatially profiling the ex… Show more
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