Molecular analysis of mutations and polymorphisms of the Lewis secretor type α(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation

Association between Norovirus and Rotavirus Infection and Histo-Blood Group Antigen Types in Vietnamese Children

“…For example, in a human volunteer challenge study, it was reported that nonsecretors were less likely to mount antibody responses upon infection, due to a lack of interactions between the NoV GII.4 virus and host HBGA receptors (13). The prevalence of the Le aϩ phenotype in Vietnamese children is similar to that reported for other countries from this region (48,49). The partial secretor (Le aϩbϩ ) phenotype observed in Asian populations is quite unique and might be associated with high levels of susceptibility to NoV. A study in Nicaragua showed an absence of this phenotype in both NoV-infected and control groups (50).…”

TaqMan‐based real‐time polymerase chain reaction for detection of FUT2 copy number variations: identification of novel Alu‐mediated deletion

“…The se 302 allele with a 302C>T (I101P) is common in South Asian populations 9,11 . The se 357,571 allele with 571C>T (R191stop) is common in a Samoan and certain Taiwanese populations, and the se 849 with 849G>A (W283stop) is common in certain Taiwanese populations 24,25 . The Se 40 , Se 481 , and se 357,480,778del alleles are African‐specific 22,26 .…”

Systematic sequence analysis of the human fucosyltransferase 2 (FUT2) gene identifies novel sequence variations and alleles

“…In contrast, most other studies genotyped a few known sequence variations of the FUT2 locus by use of diagnostic mutation detection methods such as restriction enzyme digestion 12‐17,21,22 and allele‐specific amplification 15,26 . In essence, such methods are not designed for detecting unknown sequence variations and thus seldom identify novel SNPs and alleles.…”

“…The FUT2 gene is highly polymorphic and many different sequence variations have been identified in both secretor ( Se ) and nonsecretor ( se ) alleles with race specificity 5,7‐27 . Homozygous 428G>A (W143X) is the first nonsense mutation identified and approximately 20percent of individuals in Caucasian populations are homozygous for this nonsecretor allele ( se 428 ) 5 .…”