Molecular analysis of methicillin-resistant Staphylococcus aureus dissemination among healthcare professionals and/or HIV patients from a tertiary hospital

Okado, Jessica Baleiro; Bogni, S. C.; Reinato, Lilian Andreia Fleck; Martínez, Roberto; Gir, Elucir; Camargo, Ilana Lopes Baratella da Cunha

doi:10.1590/0037-8682-0284-2015

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…Longer hospital stays, frequent use of immunosuppressants and/or antimicrobials, nutritional conditions, age, as well as the hands of health professionals are significant factors associated with HAIs (18)(19) . These factors lead to increased hospital morbidity and mortality, prolonged hospitalizations and increased costs and favor the selection and dissemination of multidrug-resistant microorganisms (20) .…”

Section: Introductionmentioning

confidence: 99%

Fatores associados à infecção por Staphylococcus aureus resistente à meticilina em unidade de terapia intensiva

2020

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Objective: To identify factors associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in adult patients admitted to the Intensive Care Unit (ICU), and to compare them with a control group. Methods: Retrospective case-control study carried out in an adult ICU, from January 2015 to June 2017, with 61 patients who developed methicillin-resistant Staphylococcus aureus infection and the same number of control patients. Results: Most participants were male 65 (60.6%), with a neurological diagnosis 43 (35.2%) and hypertensive 61 (50.0%). In the comparison of the groups, there was a statistically significant difference in relation to mechanical ventilation (p=0.0107), tracheostomy (p=0.0083), death (p=0.0401), urinary catheter (p=0.0420), length of stay (p<0.0001) and severity (p=0.0003). The main factors associated with methicillin-resistant Staphylococcus aureus infection were: severity (OR= 65.69; CI=3.726-4.808; p=0.0018), use of antimicrobials (OR= 0.047;CI=0.028-0.122;p=0.0024), length of stay (OR=1.19; CI=0.952-1.031; p=0.0285). Conclusion: methicillin-resistant Staphylococcus aureus infection is multifactorial and has been associated with length of stay and severity. Use of antimicrobials was a protective factor.

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Section: Introductionmentioning

confidence: 99%

Fatores associados à infecção por Staphylococcus aureus resistente à meticilina em unidade de terapia intensiva

2020

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“…Инфекции, вызванные MRSA, характеризуются тяжестью течения, длительной госпитализацией, большими экономическими затратами и высоким уровнем смертности, в 3 раза превышающим инфекции, вызванные MSSA [16,17]. Длительность пребывания таких пациентов на 5 дней дольше, экономические затраты на лечение в 1,7 раз больше [18]. Доля смертности -20,7 % при наличии MRSA и 6,7 % при наличии MSSA [19].…”

Section: Introductionunclassified

Molecular genetic features of MRSA and their role in the development infections in HIV-infected

Khokhlova¹,

Акушева²,

Камшилова³

et al. 2019

Immunopathol Allergol Infectol

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Изучена роль метициллинрезистентных S. aureus и их молекулярно-генетические особенности в развитии инфекций кожи и мягких тканей (абсцессов, флегмон) у ВИЧ-инфицированных. Материал для исследованиягнойное отделяемое, биоптат. Посев материала осуществляли на комплекс питательных сред по методу Gould, чувствительность определяли стандартными методами дисковой диффузии, скрининга и E-тест. Для генетических исследований MRSA получали суточную культуру и выделяли ДНК. Для генотипирования штаммов (SCCmec, spa; ST, agr) и определения генов вирулентности (42 гена) Summary HIV-infected people are at increased risk of contracting MRSA. The role of MRSA and their molecular genetic features in the development of infections of the skin and soft tissues (abscesses, cellulitis) in HIV-infected individuals were studied. The material for the study-purulent discharge, biopsy. Sowing material was carried out on a complex of culture media. Antibiotic resistance in microorganisms was determined by methods in accordance with international recommendations. For genetic studies, MRSA received a daily culture and DNA was isolated. For the genotyping of strains (SCCmec, spa; ST, agr) and the determination of virulence genes (42 genes),

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Daptomycin and vancomycin heteroresistance revealed among CC5-SCCmecII MRSA clone and in vitro evaluation of treatment alternatives

Okado

Avaca-Crusca

Oliveira

et al. 2018

Journal of Global Antimicrobial Resistance

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Molecular analysis of methicillin-resistant Staphylococcus aureus dissemination among healthcare professionals and/or HIV patients from a tertiary hospital

Cited by 7 publications

References 21 publications

Fatores associados à infecção por Staphylococcus aureus resistente à meticilina em unidade de terapia intensiva

Fatores associados à infecção por Staphylococcus aureus resistente à meticilina em unidade de terapia intensiva

Molecular genetic features of MRSA and their role in the development infections in HIV-infected

Daptomycin and vancomycin heteroresistance revealed among CC5-SCCmecII MRSA clone and in vitro evaluation of treatment alternatives

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