Molecular analysis of hepatitis B virus isolates in Mexico: Predominant circulation of hepatitis B virus genotype H

Alvarado‐Esquivel, Cosme; Sablon, Erwin; Conde-González, Carlos J; Juárez-Figueroa, Luis; Ruiz-Maya, Lilia; Aguilar-Benavides, Sergio

doi:10.3748/wjg.v12.i40.6540

Cited by 33 publications

(18 citation statements)

References 48 publications

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“…HBV genotype G has been reported in Asian, American, and western European countries [Shibayama et al, 2005; Alvarado‐Esquivel et al, 2006; De Maddalena et al, 2007; Jardi et al, 2008]. The present study identifies HBV genotype G as a minor genotype.…”

Section: Discussionsupporting

confidence: 65%

Molecular characterization of hepatitis B virus strains circulating in Belgian patients co‐infected with HIV and HBV: Overt and occult infection

Pourkarim

Lemey

Amini-Bavil-Olyaee

et al. 2011

Journal of Medical Virology

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Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) have similar transmission routes, implying that patients infected with HIV are at particular risk for HBV infection. Patients who are co-infected with HIV and HBV progress more rapidly to end-stage liver disease and different HBV genotypes may have a distinct impact on disease progression. One hundred ninety-one anti-HBc-positive sera from Belgian patients co-infected with HIV and HBV were collected during 1998-2008. Full-length HBV genomes as well as large S or partial S genes were amplified and their molecular evolutionary history was analyzed. Clinically, 30 (65.8%) patients were categorized as "overt infection" and 16 (34.7%) cases were categorized as "occult infection." Five distinct HBV genotypes comprising A (69.6%), E (19.6%), followed by D, C, and G were detected. HBV genotype A was observed in all clinical groups and in patients with varying ethnical background. HBV genotype E could be detected in African patients who were mostly infected by heterosexual contacts. Several clinically important mutations at the HBs major hydrophilic region were detected in the new isolates but with no significant difference between occult and overt infection. The high prevalence of HBV genotype A in overt and occult cases, and in particular the detection of certain HBV subgenotypes in patients co-infected with HIV and HBV that carry diagnostic escape mutations, may provide useful information for national guidelines for prophylaxis and treatment.

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Section: Discussionsupporting

confidence: 65%

Molecular characterization of hepatitis B virus strains circulating in Belgian patients co‐infected with HIV and HBV: Overt and occult infection

Pourkarim

Lemey

Amini-Bavil-Olyaee

et al. 2011

Journal of Medical Virology

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“…The presence of HBV/A significantly increases the rate of HBV/G replication in hepatocytes, although infection with HBV/G alone is possible. [46][47][48][49] Genetic rearrangements between HBV/A and HBV/G can occur during persistent coinfection. Therefore, we examined how novel Ae/G recombinants were generated and transmitted in the Japanese MSM population.…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Recombinant Forms of Hepatitis B Virus Generated from Genotypes Ae and G in HIV-1-Positive Japanese Men Who Have Sex with Men

Kojima

Kawahata

Mori

et al. 2015

AIDS Research and Human Retroviruses

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The rare hepatitis B virus (HBV) genotype G (HBV/G) coinfects HIV-1-positive individuals along with HBV/A and generates recombinants. However, the circulation of HBV A/G recombinants remains poorly understood. This molecular epidemiologic study examined HBV A/G recombinants in Japanese HIV-1-positive men who have sex with men (MSM). Initially, blood specimens submitted for confirmatory tests of HIV infection in Osaka and Tokyo, Japan, from 2006 to 2013 were examined for HIV-1, and HIV-1-positive specimens were screened for HBV. Among

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“…HBV/H is also considered an Amerindian genotype, as it is found in Central America, primarily in Mexico and Nicaragua [9,40]. Since HBV/F and HBV/H are closely related, it has been suggested that these genotypes likely split off from each other within the New World, via division of an ancestral HBV strain carried by the first settlers that entered the continent across the Bering Strait around 15,000 years ago [9,41].…”

Section: Discussionmentioning

confidence: 99%

Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil

Mello

Araujo

Lago

et al. 2013

Virol J

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BackgroundHepatitis B virus (HBV) genotype F (HBV/F) is considered to be indigenous to the Americas, but its emergence and spread in the continent remain unknown. Previously, only two HBV/F complete genome sequences from Brazil were available, limiting the contribution of Brazilian isolates to the phylogenetic studies of HBV/F. The present study was carried out to assess the proportion and geographic distributions of HBV/F subgenotypes in Brazil, to determine the full-length genomic sequences of HBV/F isolates from different Brazilian geographic regions, and to investigate the detailed evolutionary history and phylogeography of HBV/F in Brazil.MethodsComplete HBV/F genomes isolated from 12 Brazilian patients, representing the HBV/F subgenotypes circulating in Brazil, were sequenced and analyzed together with sequences retrieved from GenBank, using the Bayesian coalescent and phylogeographic framework.ResultsPhylogenetic analysis using all Brazilian HBV/F S-gene sequences available in GenBank showed that HBV/F2a is found at higher frequencies countrywide and corresponds to all sequences isolated in the Brazilian Amazon Basin. In addition, the evolutionary analysis using complete genome sequences estimated an older median ancestral age for the Brazilian HBV/F2a compared to the Brazilian HBV/F1b and HBV/F4 subgenotypes, suggesting that HBV/F2a represents the original native HBV of Brazil. The phylogeographic patterns suggested a north-to-south flow of HBV/F2a from Venezuela to Brazil, whereas HBV/F1b and HBV/F4 strains appeared to have spread from Argentina to Brazil.ConclusionsThis study suggests a plausible route of introduction of HBV/F subgenotypes in Brazil and demonstrates the usefulness of recently developed computational tools for investigating the evolutionary history of HBV.

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Molecular analysis of hepatitis B virus isolates in Mexico: Predominant circulation of hepatitis B virus genotype H

Abstract: HBV genotype H is highly predominant in HBV isolates of Mexico followed by genotypes G, A and D. A low frequency of precore and core promoter mutations is observed in HBV Mexican isolates.

Cited by 33 publications

References 48 publications

Molecular characterization of hepatitis B virus strains circulating in Belgian patients co‐infected with HIV and HBV: Overt and occult infection

Molecular characterization of hepatitis B virus strains circulating in Belgian patients co‐infected with HIV and HBV: Overt and occult infection

Identification of Novel Recombinant Forms of Hepatitis B Virus Generated from Genotypes Ae and G in HIV-1-Positive Japanese Men Who Have Sex with Men

Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil

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