Molecular Analysis of Hair Cells in Sensorineural Hearing Loss

Feng, Xiao; Qin, Zhaobing

doi:10.1159/000363683

Cited by 3 publications

(3 citation statements)

References 48 publications

(42 reference statements)

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“…Inner hair cells (IHCs), the actual sensory receptors, play a crucial role in the conversion of mechanical movements to electric signals. 8 -14 Hearing ability relies on the rapid gating of the mechanoelectrical transduction (MET) channels believed to be located in the tip of the hair cell stereocilia (Figure 2A). 15,16 The genes encoding the MET channel have not yet been identified.…”

Section: Resultsmentioning

confidence: 99%

Gene Expression Profiles of the Cochlea and Vestibular Endorgans

Nishio

Hattori

Moteki

et al. 2015

Ann Otol Rhinol Laryngol

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Objectives: We sought to elucidate the gene expression profiles of the causative genes as well as the localization of the encoded proteins involved in hereditary hearing loss. Methods: Relevant articles (as of September 2014) were searched in PubMed databases, and the gene symbols of the genes reported to be associated with deafness were located on the Hereditary Hearing Loss Homepage using localization, expression, and distribution as keywords. Results: Our review of the literature allowed us to systematize the gene expression profiles for genetic deafness in the inner ear, clarifying the unique functions and specific expression patterns of these genes in the cochlea and vestibular endorgans. Conclusions:The coordinated actions of various encoded molecules are essential for the normal development and maintenance of auditory and vestibular function.

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Section: Resultsmentioning

confidence: 99%

Gene Expression Profiles of the Cochlea and Vestibular Endorgans

Nishio

Hattori

Moteki

et al. 2015

Ann Otol Rhinol Laryngol

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“…Sensorineural hearing loss (SHL) is defined as the damage, degeneration, or loss of the cochlear hair cells (HCs) [12,13] or spiral ganglion neurons [14][15][16] in the auditory system. The majority of SHL patients are diagnosed with congenital SHL including syndromic and non-syndromic SHL.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that a total of 70-100 genetic loci are associated with SHL. These genetic loci are usually found in genes responsible for signal transduction, membrane ion channel expression, HC development, and aging processes [13]. Most of the genes are directly related to the function of the outer HCs in fine-tuning incoming sound waves.…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Sensorineural Hearing Loss as a Result of Exposure to Air Pollution

Chang

Tsai

Lee

et al. 2020

IJERPH

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Whether exposure to air pollution is associated with developing sensorineural hearing loss (SHL) remains controversial. Using data from the National Health Insurance Research Database, we recruited a total of 75,767 subjects aged older than 20 years with no history of SHL from 1998 to 2010, and they were followed up until SHL was observed, they withdrew from the National Health Insurance program, or the study ended. The subjects were evenly exposed to low-level, mid-level, and high-level carbon monoxide (CO) and nitrogen dioxide (NO2). The incidence rate ratio of SHL for patients exposed to high-level CO was 1.24 (95% confidence interval (CI) = 1.14–1.36). The NO2 pollutants increased the incidence rate ratios of SHL in mid-level NO2 and high-level NO2 exposures by 1.10 (95% CI = 1.10–1.32) and 1.36 (95% CI = 1.24–1.49) times, respectively. The adjusted hazard ratio (adj. HR) of SHL in patients exposed to high-level CO was 1.45 (95% CI = 1.31–1.59), relative to that of patients exposed to low-level CO. Compared to patients exposed to low-level NO2, patients exposed to mid-level NO2 (adj. HR = 1.40, 95% CI = 1.27–1.54) and high-level NO2 (adj. HR = 1.63, 95% CI = 1.48–1.81) had a higher risk of developing SHL. The increased risk of SHL following the increased concentrations of air pollutants (CO and NO2) was statistically significant in this study. In conclusion, the subjects’ exposure to air pollution exhibited a significantly higher risk of developing SHL in Taiwan.

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