Molecular analysis of E-cadherin and cadherin-11 in Wilms' tumours

Schulz, Stephan; Becker, Karl‐Friedrich; Braungart, Evelyn; Reichmuth, Claudia; Klamt, B; Becker, Ingrid; Atkinson, M.; Gessler, Manfred; Höfler, Heinz

doi:10.1002/(sici)1096-9896(200006)191:2<162::aid-path604>3.0.co;2-8

Cited by 21 publications

(8 citation statements)

References 31 publications

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“…Additionally, E-cadherin is consistently absent in Wilms' tumor cell lines from metastatic tumor [17]. In contrast to our study, other limited studies have not shown an association between E-cadherin expression and poor clinical outcome including metastases, recurrent tumors, and/or fatal outcomes [8,9]. Thus, our study is the first to show a clear association between decreased E-cadherin expression and high stage of disease.…”

Section: Discussioncontrasting

confidence: 86%

“…Previous studies support these findings of an association between metastatic disease and decreased E-cadherin expression [7][8][9]. In particular, 72% of Wilms' tumors exhibit significantly decreased E-cadherin expression when compared with normal control kidneys [8].…”

Section: Discussionmentioning

confidence: 52%

“…In a preliminary study, we found that tumors with 16q LOH expressed low levels of E-cadherin suggesting that decreased E-cadherin expression may be responsible for the more aggressive tumor biology associated with 16q LOH. Additionally, a number of other studies have conflicting results regarding the role of E-cadherin in the prognosis of children with Wilms' tumors [7][8][9]. These data support the role of E-cadherin as a tumor aggression gene associated with Wilms' tumors.…”

mentioning

confidence: 62%

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Decreased E-cadherin expression correlates with higher stage of Wilms' tumors

Safford

Freemerman

Langdon

et al. 2005

Journal of Pediatric Surgery

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Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 52%

mentioning

confidence: 62%

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Decreased E-cadherin expression correlates with higher stage of Wilms' tumors

Safford

Freemerman

Langdon

et al. 2005

Journal of Pediatric Surgery

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“…This data suggest that cadherin-11 might be involved in myogenesis and that rhabdomyosarcoma may re-express or fail to downregulate cadherin-11 (Markus et al, 1999). Similarly, in Wilms' tumors, there was a strong expression of cadherin-11, and in several cases it was inversely correlated with the expression of E-cadherin (Schulz et al, 2000). In our microarray-based analysis, overexpression of cadherin-11 on one hand, and downregulation of Ncadherin, on the other hand, discriminated between HR and LR ES patients.…”

Section: Discussionmentioning

confidence: 78%

Prediction of high risk Ewing's sarcoma by gene expression profiling

et al. 2004

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Ewing's sarcoma (ES) is the second most common primary malignant bone tumor in children and adolescents. Currently accepted clinical prognostic factors fail to classify ES patients' risk to relapse at diagnosis. We aimed to find a new strategy to distinguish between poor and good prognosis ES patients already at diagnosis. We analysed the gene expression profiles of 14 primary tumor specimens and six metastases from ES patients, using oligonucleotide microarray analysis. The over-expression of two genes was validated by quantitative PCR using the LightCycler system. We identified two distinct gene expression signatures distinguishing high-risk ES patients that are likely to progress from low-risk ES patients with a favorable prognosis of long-term progression-free survival. The microarray-based classification was superior to currently used prognostic parameters. Over-expressed genes in the poor prognosis patients included genes regulating the cell cycle and genes associated with invasion and metastasis, while among the downregulated genes were tumor suppressor genes and inducers of apoptosis. Our results indicate the existence of a specific gene expression signature of outcome in ES already at diagnosis, and provide a strategy to select patients who would benefit from risk-adapted improved therapy.

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“…Indeed, loss of E-cadherin expression in cancer cells may be associated with gain of N-cadherin expression, leading to a fibroblastic phenotype with increased motility and invasive potential in vitro and in vivo ( Table 2). Increase of cadherin-11 expres- sion, another mesenchymal cadherin, has also been associated with cancer cell invasion [49,204,228,248,255,278]. Formation of the human placenta, where foetal cytotrophoblast cells invade the vasculature of the uterus, is marked by a switch from E-to VE-cadherin expression [312].…”

Section: Transcriptional Stimulation Of Other (Eg N-) Cadherinsmentioning

confidence: 99%

Defective E-cadherin/catenin complexes in human cancer

et al. 2001

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Cancer is caused by a series of genomic changes leading directly or indirectly to disturbance of growth, differentiation and tissue integrity. Genomic, transcriptional or posttranscriptional alterations of E-cadherin/catenin complexes that are implicated in various steps of cancer development comprise mutational inactivation, transcriptional downregulation of E-cadherin sometimes accompanied by upregulation of N-cadherin, proteolysis of E-cadherin and posttranslational stabilisation of beta-catenin and plakoglobin. The E-cadherin/catenin complex serves not only cell-cell adhesion but also transduces signals to the nucleus and to the cytoskeleton, either directly or through its connections with multiple other complexes. We review here the expression of E-cadherin/catenin in human cancers, emphasising methods of observation and prognostic interpretation of results. This is illustrated in thyroid lesions from the benign follicular adenoma to the extremely malignant anaplastic carcinoma. The eye is an organ largely neglected by students of cadherins and catenins. The implication of a variety of members of these molecular families in the embryonic development of the eye strongly suggests that disturbances of cadherin/catenin complexes are crucial also in the development of ocular tumours.

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Molecular analysis of E-cadherin and cadherin-11 in Wilms' tumours

Cited by 21 publications

References 31 publications

Decreased E-cadherin expression correlates with higher stage of Wilms' tumors

Decreased E-cadherin expression correlates with higher stage of Wilms' tumors

Prediction of high risk Ewing's sarcoma by gene expression profiling

Defective E-cadherin/catenin complexes in human cancer

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