Molecular analysis of archived blood slides reveals an atypical human Trypanosoma infection

Deborggraeve, Stijn; Koffi, Mathurin; Jamonneau, Vincent; Bonsu, Frank; Queyson, Richard; Simarro, Pere P.; Herdewijn, Piet; Büscher, Philippe

doi:10.1016/j.diagmicrobio.2008.03.006

Cited by 60 publications

(55 citation statements)

References 20 publications

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“…The non-human-infecting trypanosomes Trypanosoma brucei brucei, Trypanosoma brucei evansi, Trypanosoma congolense, and Trypanosoma (Herpetosoma) lewisi are usually associated with animal disease but are now recognized as the potential agents of a transient, self-limiting illness in ICT humans (138,299,305,495,521,560). As most human infections with the nonhuman-infecting trypanosomes were not associated with immune deficiencies, the role of these organisms in IC patients is yet to be defined.…”

Section: Trypanosomamentioning

confidence: 99%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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SUMMARY There are many neglected nonenteric protozoa able to cause serious morbidity and mortality in humans, particularly in the developing world. Diseases caused by certain protozoa are often more severe in the presence of HIV. While information regarding neglected tropical diseases caused by trypanosomatids and Plasmodium is abundant, these protozoa are often not a first consideration in Western countries where they are not endemic. As such, diagnostics may not be available in these regions. Due to global travel and immigration, this has become an increasing problem. Inversely, in certain parts of the world (particularly sub-Saharan Africa), the HIV problem is so severe that diseases like microsporidiosis and toxoplasmosis are common. In Western countries, due to the availability of highly active antiretroviral therapy (HAART), these diseases are infrequently encountered. While free-living amoebae are rarely encountered in a clinical setting, when infections do occur, they are often fatal. Rapid diagnosis and treatment are essential to the survival of patients infected with these organisms. This paper reviews information on the diagnosis and treatment of nonenteric protozoal diseases in immunocompromised people, with a focus on patients infected with HIV. The nonenteric microsporidia, some trypanosomatids, Toxoplasma spp., Neospora spp., some free-living amoebae, Plasmodium spp., and Babesia spp. are discussed.

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Section: Trypanosomamentioning

confidence: 99%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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“…Rhodesian sleeping sickness, the human disease in East and southern Africa caused by Trypanosoma brucei rhodesiense is usually fatal within 6-8 months of infection in the absence of treatment (Odiit et al 1997 ;Fèvre et al 2004). Rhodesian sleeping sickness, if left untreated, is always fatal in humans but there have always been suggestions that self-resolving and asymptomatic chronic infections of Gambian sleeping sickness may occur but it is accepted that even if they do exist they will be few in number (Checchi et al 2008 b) or misdiagnosed due to transient infections with other trypanosome subspecies (Deborggraeve et al 2008). Critically, diagnosis and treatment of the two forms of sleeping sickness require differing approaches (Chappuis et al 2005 ;Barrett et al 2007).…”

Section: M P a C T O F S L E E P I N G S I C K N E S Smentioning

confidence: 99%

Controlling sleeping sickness – a review

2009

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SUMMARYFollowing a period characterized by severe epidemics of sleeping sickness, restoration of effective control and surveillance systems has raised the question of eliminating the disease from sub-Saharan Africa. Given sufficient political and financial support, elimination is now considered a reasonable aim in countries reporting zero or less than 100 cases per year. This success may lead health authorities across the affected region to downgrade the disease from ‘neglected’ to simply being ignored. In view of the significant levels of under-reporting of sleeping sickness mortality in rural communities, this could be a short-sighted policy. Loss of capacity to deal with new epidemics, which can arise as a consequence of loss of commitment or civil upheaval, would have serious consequences. The present period should be seen as a clear opportunity for public-private partnerships to develop simpler and more cost-effective tools and strategies for sustainable sleeping sickness control and surveillance, including diagnostics, treatment and vector control.

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“…58 Interestingly, this compound contains a C-alkylthiazole with an isopropyl chain, a structural feature that seems to promote antimalarial activity. Overall, five of the most active compounds, all alkene linked, contained a C-alkylthiazole (compounds [33][34][35][36][37][38][39][40][41]. Even in the weakly active amidine series, the Calkylthiazole noticeably increased the activity.…”

Section: Anti-malarial Minor Groove Bindersmentioning

confidence: 99%

DNA Minor Groove Binders-Inspired by Nature

Khalaf¹,

Al-kadhimi²,

Ali³

2016

ACSi

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The synthesis and biological activity of a variety of analogues to the naturally occurring antibacterial and antifungal Distamycin A were explored by a number of authors. These compounds were subject to a large array of assays. Some of these compounds showed high activity against a range of Gram-positive, Gram-negative bacteria as well as fungi. To explore the anti-parasitic activity of this class of compounds, specific modifications had to be made. A number of these compounds proved to be active against Trypanosoma brucei. The binding of a number of these compounds to short sequences of DNA were also examined using footprinting assays as well as NMR spectroscopy. Computer modelling was employed on selected compounds to understand the way these compounds bind to specific DNA sequences. A large number of variations were made to the standard structure of Distamycin. These changes involved the replacement of the pyrrole moieties as well as the head and tail groups with a number of heterocyclic compounds. Some of these minor groove binders (MGBs) were also investigated for their capability for the treatment of cancer and in particular lung cancer.

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Molecular analysis of archived blood slides reveals an atypical human Trypanosoma infection

Cited by 60 publications

References 20 publications

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Controlling sleeping sickness – a review

DNA Minor Groove Binders-Inspired by Nature

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