Molecular Alterations in Oral Carcinogenesis: Significant Risk Predictors in Malignant Transformation and Tumor Progression

Shah, Neelam G.; Trivedi, Trupti; Tankshali, Rajen A; Goswami, Jyotirup; Shah, Jigna S; Jetly, Dhaval; Kobawala, Toral P; Patel, K.C.; Shukla, Shilin N.; Shah, Pankaj; Verma, Richa

doi:10.1177/172460080702200207

Cited by 41 publications

(59 citation statements)

References 48 publications

(45 reference statements)

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“…Several studies have analyzed c-myc expression in this type of tumor showing different results, with an average positivity of 41.28% (2.4-75%) between the different studies (6,(26)(27)(28)(29)(30)(31)(32)(33)(34). The results are extremely contradictory, as well as the variation in the quantification methods.…”

Section: Discussionmentioning

confidence: 74%

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Quantitative determination of c-myc facilitates the assessment of prognosis of OSCC patients

et al. 2014

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Abstract.Myc genes are a family of proto-oncogenes whose proteins are implicated in the regulation of cell proliferation, differentiation and apoptosis, and in regulating the activity of genes involved in cell division. The aim of the present study was to establish a quantitative description of the expression of c-myc and evaluate its relationship with other clinical and prognostic factors, as well as to establish a multivariate survival prediction model. This is a retrospective study of 68 patients diagnosed with oral squamous cell carcinoma (OSCC). We constructed a tissue microarray for investigating the expression of c-myc by immunohistochemistry. Statistical analyses were carried out, and a multivariate model that predicts survival was established. The average expression of c-myc was 50.32 (SD, 26.05) with a range from 6.60 to 99.

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Section: Discussionmentioning

confidence: 74%

“…Shah et al (30) described an odds ratio (OR) of 6 in the transformation from hyperplasia to dysplasia, for c-myc (+) lesions and an OR of 3 for progressions beyond early stage carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Quantitative determination of c-myc facilitates the assessment of prognosis of OSCC patients

et al. 2014

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“…3 p53 expression in OSCC apparently does not correlate with differentiation grade but has been associated with patient outcome. 4,5 The CDKN2A gene is inactivated in approximately 70% of human cancers. 6 Its codified protein p16…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical expression of p53, p16 and hTERT in oral squamous cell carcinoma and potentially malignant disorders

Abrahão

Bonelli²,

Nunes

et al. 2011

Braz. oral res.

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Oral carcinogenesis is a multi-step process. One possible step is the development of potentially malignant disorders known as leukoplakia and erytroplakia. The objective of this study was to use immunohistochemistry to analyze the patterns of expression of the cell-cycle regulatory proteins p53 and p16INK4a in potentially malignant disorders (PMD) of the oral mucosa (with varying degrees of dysplasia) and in oral squamous cell carcinomas (OSCC) to correlate them with the expression of telomerase (hTERT). Fifteen PMD and 30 OSCC tissue samples were analyzed. Additionally, 5 cases of oral epithelial hyperplasia (OEH) were added to analyze clinically altered mucosa presenting as histological hyperplasia without dysplasia. p53 positivity was observed in 93.3% of PMD, in 63.3% of OSCC and in 80% of OEH. Although there was no correlation between p53 expression and the grade of dysplasia, all cases with severe dysplasia presented p53 suprabasal immunoexpression. p16INK4a expression was observed in 26.7% of PMD, in 43.3% of OSCC and in 2 cases of OEH. The p16INK4a expression in OEH, PMD and OSCC was unable to differentiate non-dysplastic from dysplastic oral epithelium. hTERT positivity was observed in all samples of OEH and PMD and in 90% of OSCC. The high hTERT immunoexpression in all three lesions indicates that telomerase is present in clinically altered oral mucosa but does not differentiate hyperplastic from dysplastic oral epithelium. In PMD of the oral mucosa, the p53 immunoexpression changes according to the degree of dysplasia by mechanisms independent of p16 INK4a and hTERT.

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“…For this reason, several studies have been performed on the biological patterns of the tumor, which are closely connected with its behavior (greater or lesser aggressiveness) and can predict the prognosis. Oncogenes expressed at varying percentages and associated modifications of chromosomal sites have been identified in oral tumors (4)(5)(6)(7)(8)(9)(10)(11)(12)(13). The p53 tumor suppressor gene (expressed in 4-50% of cases) is the most studied oncogene detected on chromosome 17, and it is clear that preliminary knowledge of the p53 status may be of great assistance in managing OSCC (14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

p53 as a prognostic marker associated with the risk of mortality for oral squamous cell carcinoma

et al. 2016

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Abstract. Oral squamous cell carcinoma (OSCC) is often associated with a poor prognosis. The purpose of the present study was to investigate survival and the risk of mortality in OSCC with regard to stage, tumor site and p53 expression. A retrospective study was performed on 150 non-consecutive cases of OSCC that were observed between January 1992 and January 2012, and were selected from a total of 580 patients according to the criteria of the homogeneity of histopathological grading (G2). The medical records were reviewed for 48 cases with disease at stage I [37 males, age 64.7±5.7 years (mean age±standard deviation); 11 females, age 70.0±3.37 years]; 27 cases with stage II (15 males, age 64.5±5.6 years; 12 females, age 69.2±3.9 years); 58 cases with stage IVa (42 males, age 66.9±5.3 years; 16 females, age 64.2±6.5 years); and 17 cases with stage IVb (16 males, age 65.7±5.4 years; 1 female, age 69 years). Monoclonal p53 antibody (clone DO-7) was used to perform the p53 immunohistochemical study. A significant association was found between the site of the tumor and p53 overexpression (P<0.0001). Stage I-II cases showed a higher cumulative probability of a 24-month survival time than stage IVa-IVb cases (P<0.0001). Cheek, floor and soft palate tumors showed a worse prognosis (P<0.0001) and tumors with p53 overexpression >50% showed a poor survival rate (P<0.0001) compared with tumors of the attached gingiva, tongue and retromolar trigone. The findings allowed the quantification of the risk mortality from OSSC with regard to stage, tumor site and the p53 expression pattern of the tumor.Data supported the absolute indications for wide surgical margins (radical surgery) in cases of T1-T2 N0 tumors of the tongue, floor, retromolar trigone and attached gingiva when p53 overexpression is >50% in association with a higher risk of mortality compared with when p53 overexpression is <50%.

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Molecular Alterations in Oral Carcinogenesis: Significant Risk Predictors in Malignant Transformation and Tumor Progression

Cited by 41 publications

References 48 publications

Quantitative determination of c-myc facilitates the assessment of prognosis of OSCC patients

Quantitative determination of c-myc facilitates the assessment of prognosis of OSCC patients

Immunohistochemical expression of p53, p16 and hTERT in oral squamous cell carcinoma and potentially malignant disorders

p53 as a prognostic marker associated with the risk of mortality for oral squamous cell carcinoma

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