Molecular Affinity and Permeability of Different Molecular Weight Chitosan Membranes

Chen, Xi Guang; Zheng, Li; Wang, Zhen; Lee, Chang Yong; Park, Hyun Jin

doi:10.1021/jf020151g

Cited by 86 publications

(41 citation statements)

References 27 publications

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“…dielectric spectroscopy, concentration polarization, simulation, chitosan, adsorption, release Chitosan, a natural macromolecule with unique biocompatibility and adsorption property, is widely used in medical, agricultural and biological fields [1][2][3] . The related adsorption theory and controlled-release technology have been the topics of great interest.…”

mentioning

confidence: 99%

Dielectric study on membrane adsorption and release: Relaxation mechanism and diffusion dynamics

Zhao

Han

2008

Sci. China Ser. B-Chem.

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Dielectric monitoring of the adsorption or release process of salicylic acid (SA) by chitosan membrane shows that the dielectric spectra of the chitosan membrane/ SA solution systems change regularly in the adsorption or release process. By analyzing the regularity, a new mechanism for the relaxations is proposed. The concentration polarization layer (CPL) caused by SA adsorption or release is confirmed to be essential for the dielectric relaxations. The changes of the spectra with time are explained by account of the relationship between CPL properties and dielectric strength. Based on this relaxation mechanism, a theoretical method can be established to calculate dynamical parameters of inner structure of the adsorption or release systems from their dielectric spectra. Therefore, dielectric spectroscopy is demonstrated to be a promising method for estimating interfacial distribution of ionic substances and their binding to membrane in a non-invasive way.

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mentioning

confidence: 99%

Dielectric study on membrane adsorption and release: Relaxation mechanism and diffusion dynamics

Zhao

Han

2008

Sci. China Ser. B-Chem.

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“…Materials with different molecular weight of chitosan have different properties, Such as the antibacterial properties, permeation resistance [20,21], the rate of drug loading and releasing [22], drug delivery efficiency [23], pollutant removal properties [24]. So the measurement of chitosan molecular weight is of great importance.…”

Section: Methodsmentioning

confidence: 99%

Directly determining the molecular weight of chitosan with atomic force microscopy

Zhang¹,

Li²,

Zhang³

et al. 2016

Front Nanosci Nanotech

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Molecular weight will not only affect cytotoxicity, viscosity and other basic properties of molecules in physical and chemical fields, but also influence its efficiency of drug delivery in nanomaterial fields. It is of great importance to measure the molecular weight of a substance. In this study, we proposed a new method to directly determine the molecular weights of polymers with linear and repeated molecular structures. An empirical molecular weight formula of Chitosan with different molecular weights were chosen to value our new proposed method. Our results imply that the molecular weight of chitosan obtained with the new method is reasonable. Moreover, the distributions of molecular weight and molecular lengths can also be acquired at the same time with this novel method.

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“…CTS (relative molecular mass 7 1.1 10 × , deacetylation degree 80%) was prepared in our laboratory by the method of acetic acid hydrolyzes referenced from Chen et al [12] . All other chemicals and reagents used were of analytical grade and provided by Shanghai Chemical Reagent Company (USA).…”

Section: Methodsmentioning

confidence: 99%

Comparison study of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres

Ruo-bao

Zhao

Zhang

et al. 2009

Wuhan Univ. J. Nat. Sci.

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To compare two microspheres of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin loaded theophylline as pulmonary sustained drug delivery carriers, the characteristics and ciliotoxicity were studied. The drug loadings of chitosan/ β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 21.09% and 21.42%, and the encapsulation efficiencies were 91.40% and 92.80%. The distributions of 50% (d 0.5 ) of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 4.89 and 5.83 μm, respectively. Both microspheres showed spherical shape with smooth or wrinkled surfaces. FT-IR of chitosan/β-cyclodextrin microspheres demonstrated that theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin, while for the carboxymethyl chitosan/β-cyclodextrin microspheres theophylline had interaction with carboxymethyl chitosan. The moisture absorption showed that an equilibrium was reached within 24 h. The two microspheres possessed better adaptability. In vitro release of theophylline from chitosan/ β-cyclodextrin microspheres was slower than that from carboxymethyl chitosan/β-cyclodextrin microspheres at pH 6.8.

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Molecular Affinity and Permeability of Different Molecular Weight Chitosan Membranes

Cited by 86 publications

References 27 publications

Dielectric study on membrane adsorption and release: Relaxation mechanism and diffusion dynamics

Dielectric study on membrane adsorption and release: Relaxation mechanism and diffusion dynamics

Directly determining the molecular weight of chitosan with atomic force microscopy

Comparison study of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres

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