Molecular access to multi-dimensionally encoded information

Steinkoenig, Jan; Aksakal, Resat; Prez, Filip Du

doi:10.1016/j.eurpolymj.2019.109260

Cited by 29 publications

(26 citation statements)

References 60 publications

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“…An attractive solution to tackle this issue is multidimensional storage, [ 22 ] with digital polymers ordered at discrete locations onto surfaces (2D) [ 23 ] or in layers (3D). [ 24 ] While there is no method currently available to read 3D patterns by MS/MS, ionization techniques capable of surface sampling have been used to decipher molecularly encoded information.…”

Section: Introductionmentioning

confidence: 99%

Desorption Electrospray Ionization (DESI) of Digital Polymers: Direct Tandem Mass Spectrometry Decoding and Imaging from Materials Surfaces

Amalian

Mondal

Konishcheva

et al. 2021

Adv Materials Technologies

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Sequence‐defined synthetic polymers have recently emerged as an attractive medium to store information at the molecular level, where comonomers of the chains are defined as letters of an alphabet. The main read‐out methodology employed to retrieve such molecularly encoded information is tandem mass spectrometry (MS/MS), but a major current limitation remains the low storage capacity of readable chains. Ordering short oligomers at discrete locations onto surfaces to compose long messages is an attractive alternative to the difficult synthesis of long coded polymers. Yet, such surface storage requires a reliable sampling technique to be coupled on‐line with MS/MS. Because it combines fast surface extraction with efficient analyte ionization in ambient conditions, desorption electrospray ionization (DESI) is shown here to be perfectly suited to envisage bidimensional data storage. The present study demonstrates performances of DESI‐MS/MS at mapping oligomers used to write letters of a word, extracting digital labels from materials tagged for anticounterfeiting purposes, and imaging text written with coded polymeric inks.

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Section: Introductionmentioning

confidence: 99%

Desorption Electrospray Ionization (DESI) of Digital Polymers: Direct Tandem Mass Spectrometry Decoding and Imaging from Materials Surfaces

Amalian

Mondal

Konishcheva

et al. 2021

Adv Materials Technologies

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“…These include, reliability as a result of possible degradation, a restricted number of building blocks (i.e., the monomer alphabet), limited rewritability, and cost. [ 15,20,24,25 ] In order to solve some of the drawbacks related to DNA, the use of discrete synthetic macromolecules has emerged as a viable alternative for data encoding at the molecular level and has the potential to greatly enhance data storage capacity. [ 10,11,15–17,20,26 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 18,19 ] As a result, polymer chemists are turning their interests toward a more compact and durable chemical solution. [ 11,20 ] While nonbiological information storage has already been successfully demonstrated using DNA, [ 21,22 ] along with its read‐out using DNA sequencing, [ 23 ] there are drawbacks when considering this as a feasible data storage medium. These include, reliability as a result of possible degradation, a restricted number of building blocks (i.e., the monomer alphabet), limited rewritability, and cost.…”

Section: Introductionmentioning

confidence: 99%

From Sequence‐Defined Macromolecules to Macromolecular Pin Codes

et al. 2020

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Dynamic sequence‐defined oligomers carrying a chemically written pin code are obtained through a strategy combining multicomponent reactions with the thermoreversible addition of 1,2,4‐triazoline‐3,5‐diones (TADs) to indole substrates. The precision oligomers are specifically designed to be encrypted upon heating as a result of the random reshuffling of the TAD‐indole covalent bonds within the backbone, thereby resulting in the scrambling of the encoded information. The encrypted pin code can eventually be decrypted following a second heating step that enables the macromolecular pin code to be deciphered using 1D electrospray ionization‐mass spectrometry (ESI‐MS). The herein introduced concept of encryption/decryption represents a key advancement compared with current strategies that typically use uncontrolled degradation to erase and tandem mass spectrometry (MS/MS) to analyze, decipher, and read‐out chemically encrypted information. Additionally, the synthesized macromolecules are coated onto a high‐value polymer material, which demonstrates their potential application as coded product tags for anti‐counterfeiting purposes.

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“…16 In another context, sequence-dened macromolecules offer promising approaches to data storage through the use of monomer units as bits. 17 For example, with two comonomers dened as 0 and 1, binary information can be written. 18 Depending on the type of polymer backbone, the size of individual monomeric units varies between 2 to 10Å, which result in higher information density compared to conventional storage media used today.…”

Section: Introductionmentioning

confidence: 99%