Mold fungi in the etiology of respiratory allergic diseases

Browning, William H.

doi:10.1016/s0021-8707(43)90643-4

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…studying Phytophtora, found that the type and concentration of the nitrogen source, the amount of inoculum, and the age of the mycelium greatly affected the antigen distri bution in preparations of this mold. Aller gen extracts of molds have also been report ed to contain irritants restricting their clini cal value [7]. An extract of C. herbarum (Ch-76) has been characterized previously using quantitative immunoelectrophoretic techniques, but preliminary attempts to identify the allergens in this extract were not conclusive due to the low number of patient sera employed [15].…”

Section: Herbarummentioning

confidence: 99%

Crossed Radioimmunoelectrophoretic Studies of Distinct Allergens in Two Extracts of Cladosporium herbarum

Aukrust¹

1979

Int Arch Allergy Immunol

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Cladosporium herbarum was supplied from two sources and extracted identically. Antisera against the extracts were produced in rabbits and two reference patterns were established using crossed immunoelectrophoresis (CIE). Both patterns showed more than 60 precipitates but less than 50% of the detectable antigens appeared to be identical in the two extracts. The allergens were identified by means of crossed radioimmunoelectrophoresis (CRIE) using sera from 35 individuals with proven or suspected allergy to C. herbarum. Four important and 10–20 less important allergens were demonstrated. Among the allergens present, there were none reacting with all patient sera. Only 1 out of 3 rabbits immunized with a suspension of broken cells of C. herbarum showed precipitating antibodies to the statistically most important allergen, while 9 rabbits immunized with aqueous extracts of the mold did not. The composition of the two extracts with respect to allergens differed. Allergens present in one extract were not always detectable in the other. The experiments also showed how CIE/CRIE with various combinations of antigens and antisera may be combined with CRIE inhibition, radioallergosorbent test (RAST) and RAST inhibition for comparing complex allergen extracts at the molecular level.

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Section: Herbarummentioning

confidence: 99%

Crossed Radioimmunoelectrophoretic Studies of Distinct Allergens in Two Extracts of Cladosporium herbarum

Aukrust¹

1979

Int Arch Allergy Immunol

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“…It has previously been reported that commercial extracts of moulds may be highly unreliable when used in intracutaneous skin tests and in bronchial challenges, due to the unsatisfactory quality of the extracts (1,3,7,8,12,17,23,24). It is necessary to identify which of the most abundant atmospheric moulds contribute significantly to the allergic disease in question.…”

Section: Discussionmentioning

confidence: 99%

“…For this purpose, in addition to a thorough histoi-y, diagnostic tests, such as skin testing, radioallergosorbent tests and challenge tests, are performed with allergen extracts from the most common moulds. It has previously been reported that commercial extracts of moulds may be highly unreliable when used in intracutaneous skin tests and in bronchial challenges, due to the unsatisfactory quality of the extracts (1,3,7,8,12,17,23,24).…”

Section: Discussionmentioning

confidence: 99%

Immediate Type Hypersensitivity to Common Moulds Comparison of Different Diagnostic Materials

K¹,

Leegaard²,

Aukrust³

et al. 1980

Allergy

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Extracts of five common atmospheric moulds (Alternaria, Aspergillus, Cladosporium, Mucor and Penicillium) obtained from different manufacturers were compared by means of skin prick testing and, partly, with the radioallergosorbent test. Considerable differences were found between the extracts with respect to positive tests found in mould-allergic individuals and controls. A purified allergen preparation of Cladosporium herbarum was superior to the crude allergen extracts. The results suggest that the allergen contents of the extract differed both with respect to total allergenic potency and to allergenic composition.

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“…These criteria were not satisfied with ordinary or conven tional types of dried pellicle extracts which were often non-specifically irritating or so relatively impotent that they were diagnosti cally unreliable except in occasional instances of high degree of sensitization (2). Recheck by passive transfer did not always resolve the diagnostic uncertainties with the use of such allergens.…”

Section: Skin Tests With Moldsmentioning

confidence: 96%

Fungi and Bacteria in the Etiology of Respiratory Allergic Diseases XX. Mold Allergy in Pediatric Practice

Prince¹,

Houston²,

Texas³

et al. 1959

Int Arch Allergy Immunol

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Mold fungi in the etiology of respiratory allergic diseases

Cited by 5 publications

References 6 publications

Crossed Radioimmunoelectrophoretic Studies of Distinct Allergens in Two Extracts of <i>Cladosporium herbaru</i><i>m</i>

Crossed Radioimmunoelectrophoretic Studies of Distinct Allergens in Two Extracts of <i>Cladosporium herbaru</i><i>m</i>

Immediate Type Hypersensitivity to Common Moulds Comparison of Different Diagnostic Materials

Fungi and Bacteria in the Etiology of Respiratory Allergic Diseases XX. Mold Allergy in Pediatric Practice

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