Moisturizing and antiinflammatory properties of cosmetic formulations containing Centella asiatica extract

Kang

et al. 2018

IJMS

8-Hydroxydaidzein (8-HD) is a daidzein metabolite isolated from soybeans. This compound has been studied for its anti-proliferation, depigmentation, and antioxidant activities. However, the anti-inflammatory activities of 8-HD are not well-understood. Through its antioxidant effects in ABTS and DPPH assays, 8-HD reduces the production of sodium nitroprusside (SNP)-induced radical oxygen species (ROS). By triggering various Toll-like receptors (TLRs), 8-HD suppresses the inflammatory mediator nitric oxide (NO) without cytotoxicity. We examined the regulatory mechanism of 8-HD in lipopolysaccharide (LPS)-induced conditions. We found that 8-HD diminishes inflammatory gene expression (e.g., inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, and tumor necrosis factor (TNF)-α) by regulating the transcriptional activities of nuclear factor (NF)-κB and activator protein 1 (AP-1). To find the potential targets of 8-HD, signaling pathways were investigated by immunoblotting analyses. These analyses revealed that 8-HD inhibits the activation of TAK1 and that phosphorylated levels of downstream molecules decrease in sequence. Together, our results demonstrate the antioxidant and anti-inflammatory actions of 8-HD and suggest its potential use in cosmetics or anti-inflammatory drugs.

Section: Discussionmentioning

confidence: 99%

The Antioxidant and Anti-Inflammatory Activities of 8-Hydroxydaidzein (8-HD) in Activated Macrophage-Like RAW264.7 Cells

Kang

et al. 2018

IJMS

“…In addition, the hydration and epidermal barrier function of the subjects in emulsion formulation group was better than that of hydrogel formulation group. Therefore, C. asiatica can be used in moisturizing cosmetic formulations (Ratz-Lyko et al, 2016). Clinical studies also confirmed the effect of C. asiatica against generalized anxiety disorder, but the level of evidence was low and the number of patients was rather small (Jana et al, 2010).…”

Section: Clinical Trials Of C Asiaticamentioning

confidence: 99%

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun

et al. 2020

Front. Pharmacol.

147

Centella asiatica (also known as Centella asiatica (L.) Urb. or Gotu kola) is a traditional Chinese medicine with extensive medicinal value, which is commonly used in Southeast Asian countries. This study aimed to summarize the effects of C. asiatica and its main components on neurological diseases, endocrine diseases, skin diseases, cardiovascular diseases, gastrointestinal diseases, immune diseases, and gynecological diseases, as well as potential molecular mechanisms, to study the pathological mechanism of these diseases based on the changes at the molecular level. The results showed that C. asiatica and its triterpenoids had extensive beneficial effects on neurological and skin diseases, which were confirmed through clinical studies. They exhibited anti-inflammatory, antioxidative stress, anti-apoptotic effects, and improvement in mitochondrial function. However, further clinical studies are urgently required due to the low level of evidence and lack of patients.

“…It contains biologically active compounds such as asiatic acid, madecassic acid, asiaticoside, and madecassoside 12,14 . Due to its ability to stimulate collagen synthesis, C. asiatica has been used in cream, gel, or topical spray formulations for restoring skin firmness and elasticity and improving its appearance 12,15 . In addition, there are reports that both C. asiatica and C. odorata have antibacterial and antioxidant activities 3, 13 .…”

mentioning

confidence: 99%

Untitled

2020

IJPSR

Chromolaena odorata was extracted by ethanol/water. Centella asiatica was extracted by methanol. A cream containing C. odorata and C. asiatica extracts was formulated and evaluated for its physicochemical properties and stability. C. odorata and C. asiatica were extracted and their respective active compounds scutellarein tetramethyl ether and asiaticoside were determined as bioactive compounds using HPLC. Creams were prepared using 5% C. odorata and 1% C. asiatica extracts and tested for their appearance, pH, and viscosity. Stability was evaluated under accelerated conditions using six hot/cold cycles and after long-term storage at 30 C/75% RH for 3 months. The content of scutellarein tetramethyl ether in C. odorata extract was 0.13 ± 0.02% w/w and the content of asiaticoside in the C. asiatica extract was 0.35 ± 0.04% w/w. Contents of scutellarein tetramethyl ether and asiaticoside in the cream formulation were 98.25 ± 0.43% and 102.16 ± 0.22%, respectively. The cream formulations containing the extracts had a good appearance and were non-greasy and easily applied, with a pH value of 5.4 ± 0.1 and viscosity of 1604 ± 257 poises determined at shear rate 0.08 s-1. No changes in physical and chemical properties occurred during storage. These findings indicate that this formulation of 5% C. odorata and 1% C. asiatica extract is stable and suitable for further testing as a topically applied product.