Moisture sorption and tensile strength of some tableted direct compression excipients

Malamataris, S.; Goidas, P.; Dimitriou, Alexandra

doi:10.1016/0378-5173(91)90126-9

Cited by 66 publications

(42 citation statements)

References 18 publications

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“…4 were fitted using least squares regression to the GAB equation. The parameters listed in Table II are similar to the ranges reported in the literature (3,6,7,10,12,24). With the exception of PVP, all of the powders showed s-shaped adsorption isotherms indicating type II isotherms.…”

Section: Discussionsupporting

confidence: 69%

The Effect of Moisture on the Flowability of Pharmaceutical Excipients

2013

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Abstract. The effect of moisture content on flowability of six pharmaceutical powders (microcrystalline cellulose (MCC), hydroxypropyl methylcellulose (HPMC), carboxymethyl cellulose (CMC), polyvinylpyrrolidone (PVP), corn starch, and potato starch) was investigated. Powder flowability was measured using established static techniques and emerging dynamic avalanche behavior measurements. Static techniques did not provide enough resolution to clearly identify changes in flowability due to increasing powder moisture content. Avalanche time and its standard deviation showed that flowability of MCC, CMC, PVP, and potato starch decreased after a critical moisture content, flowability of corn starch increased and flowability did not significantly change for HPMC. The moisture decreased flowability by forming stronger interparticle liquid bridges and increased flowability by acting as a lubricant. The dynamic density of the celluloses and PVP decreased linearly with increasing moisture content as the particles swelled with water. The starches also swelled and decreased in dynamic density, but only after a moisture content corresponding to monolayer coverage of water around the particles was reached. As flowability and dynamic density change with moisture content, to ensure consistent production of high-quality tablets, the moisture content of the powders must be measured and controlled.

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Section: Discussionsupporting

confidence: 69%

The Effect of Moisture on the Flowability of Pharmaceutical Excipients

2013

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“…Shukla and Price (1991b) reported a reduced RTS on increasing water content for lactose. Moisture was reported to reduce bonding between paracetamol particles (Khan et al, 1981;Li and Peck, 1990;Malamataris et al, 1991). By increasing compression pressure/speed at high Aw, ER 0 was increased for MCC.…”

Section: Effect Of Aw On Elastic Recovery (Er 0 ) and Radial Tensile mentioning

confidence: 94%

Radial die-wall pressure as a reliable tool for studying the effect of powder water activity on high speed tableting

Abdel-Hamid

Betz

2011

International Journal of Pharmaceutics

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“…Ng, Kwek, and Tan (2007) reported that storage conditions after micronization could influence the particle size. Interaction between moisture sorption and excipients influenced the physical and chemical stabilities of the product, control of drug release, and property of the solid dosage form and excipient (Garr & Rubinstein, 1992;Malamataris, Goidas, & Dimitriou, 1991;Nokhodchi, Javadzadeh, Siahi-Shadbad, & Barzegar-Jalali, 2005). Moisture sorption also affected the drug dispersion and de-agglomeration behavior, which in turn impacted the performance of respiratory drug delivery.…”

Section: Introductionmentioning

confidence: 97%

“…Salbutamol sulfate and lactose monohydrate (Inhalac 230 ᭨ ) were chosen as the model DPI compounds since their physical and chemical properties are well known. Based on the measured sorption isotherms, the nature of moisture sorption was evaluated using two theoretical models: the GAB model and Young-Nelson equations (Chan & Pilpel, 1983;Garr & Rubinstein, 1992;Malamataris et al, 1991;York, 1981). Aerosolization performance was evaluated in terms of the drug emission, drug dispersion, and FPF using a twin-stage impinger (TSI).…”

Section: Introductionmentioning

confidence: 99%