Moisture absorption modeling using design of experiments

Yong, Virginia; Hahn, Hoh‐Gyu

doi:10.1002/app.25219

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…Figures 2B and 2C show the weight loss of all samples, indicating the rst decomposition stage below 100 °C. This loss might have been due to moisture elimination (29,30). The blank solvent-cast polymeric lms showed two stages of weight loss: (I) in the 139-226°C temperature range, with maximum temperature at 184.23°C, 197.01°C, and 191.68°C, and (II) in the 221-327°C temperature range, with maximum temperature at 254.06°C, 245.98°C, and 236.03°C for the FB01, FB02, and FB03 formulations, respectively.…”

Section: Resultsmentioning

confidence: 99%

Solvent‐Cast Polymeric Films from Pectin and Eudragit® NE 30D for Transdermal Drug Delivery Systems

et al. 2021

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In this study, solvent-cast polymeric lms containing ionic liquid lidocaine/aspirin for transdermal patches were developed. Solvent-cast polymeric lms were prepared from two polymers, pectin and Eudragit ® NE 30D, by drying the polymeric solution in a hot air oven at 70 ± 3°C for 10 hrs. Glycerin was used as a plasticizer. Lidocaine and aspirin were prepared in ionic liquid form and loaded into the patches. The physicomechanical properties of the lms were characterized by texture analysis, differential scanning calorimetry, thermogravimetric analysis, and X-ray diffraction. A scanning electron microscope was used to photograph the surfaces of solvent-cast polymeric lms. Eudragit ® NE 30D signi cantly decreased the toughness and rigidity of the lms. The transdermal patches were in the amorphous state, and their thermal properties were not changed from blank polymeric lms. The surfaces of transdermal patches were rougher than blank polymeric lms and revealed the distribution of the drug. Eudragit ® NE 30D signi cantly decreased the trends of entrapment e ciency and in vitro release of lidocaine and aspirin drugs. The kinetic release observed in vitro tted to Higuchi's model rather than zero and rst order models, indicating that a diffusion mechanism governed the release of the drug from the patch. Thus, the solvent-cast polymeric lms from two polymers, pectin and Eudragit ® NE 30D, are suitable for transdermal patches loaded with ionic liquid lidocaine/aspirin.

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Section: Resultsmentioning

confidence: 99%