Moist Exposed Burn Ointment (MEBO) Dressing in Treatment of Equine Limb Distal Wounds

Moustafa, Alaa

doi:10.5455/ajvs.209977

Cited by 3 publications

(3 citation statements)

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“…Analysis of digital images and histopathological scores of treated wounds using MEBO in this study has shown better wound healing as indicated by better epithelialization area, faster contraction, lower wound area percentage, and a significantly higher degree of angiogenesis when compared with honey-treated wounds and control wounds. These findings are similar to previously reported data [ 9 - 12 ]. It has been found that MEBO prevents bacteria from deeply penetrating wounded tissues and inhibits the proliferation of microorganisms laden in the wound bed [ 9 - 12 ].…”

Section: Discussionsupporting

confidence: 94%

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Wound healing in immunocompromised dogs: A comparison between the healing effects of moist exposed burn ointment and honey

et al. 2020

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Background and Aim: Natural topical products have been used to enhance wound healing, especially in immunocompromised animals. The aims of this study were to evaluate and to compare the effects of moist exposed burn ointment (MEBO) and honey on the healing of full-thickness skin wounds in immunocompromised dogs. Materials and Methods: The study was conducted using 12 adults, apparently healthy mongrel dogs. Immunosuppression was induced in six dogs by oral administration of prednisone (2 mg/kg) and azathioprine (2 mg/kg), once a day for 21 days. On each dog, a total of 9, 1.5 cm in diameter full-thickness skin circular wounds were created aseptically in the thoracolumbar area under general anesthesia using customized skin punch biopsy kit. In a random fashion, three wounds in each dog were treatment using MEBO (contains b-sitosterol, baicalin, and berberine as active ingredients in a base of beeswax and sesame oil), honey or no treatment (control), once per day for 21 days. Wounds were grossly evaluated once a day for signs of inflammation or infection. In addition, biopsy specimens and digital imaging data of each wound were obtained on days 7, 14, and 21 for histopathological evaluation of the healing process. Results: Wounds in immunocompromised dogs appeared to heal significantly in a slower fashion than in non-immunocompromised counterparts. Digital analysis data showed that MEBO-treated wounds expressed better epithelialization area, faster contraction, and smaller wound area percentage when compared with honey-treated wounds. Histopathological analysis showed significantly higher angiogenesis scores in MEBO-treated wounds when compared with other treatments. Conclusion: Results of this study showed that MEBO resulted in significant enhancement of wound healing in both healthy and immunocompromised dogs. However, when compared to honey, the wound healing effect of MEBO was superior to that of honey.

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Section: Discussionsupporting

confidence: 94%

“…It has been found that MEBO prevents bacteria from deeply penetrating wounded tissues and inhibits the proliferation of microorganisms laden in the wound bed [ 9 - 12 ]. Similar to previously reported findings, rapid re-epithelialization was observed in MEBO-treated animals [ 9 - 12 ].…”

Section: Discussionmentioning

confidence: 99%

Wound healing in immunocompromised dogs: A comparison between the healing effects of moist exposed burn ointment and honey

et al. 2020

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“…Also, our results agree with another study done by Moustafa on the equine wound model in horses; they found that Mebo significantly accelerated the wound healing process and reduce wound closure in comparison with the control group. 11 Also, vitamin K has increased the rate of wound closure, and this result agrees with the result of the previous study have been reported by Hemmati and coworkers. 12 Additionally, all experimental groups of rats showed significant results in the level of TGF-B1 expression and the most significant results of TGF-B1 expression at day 21 of treatment was shown in MK, CK, and K rat groups in which the mean level of TGF-B1 expression was (87.5, 66.5, and 63.5 pg/ ml) respectively, so the highest level of TGF-B1 expression was found in MK rat groups in comparison of the control group of rats as shown in (Table 2).…”

Section: (B) (A)supporting

confidence: 92%

The effect of vitamin K on the wound healing process in rat skin achieved by common wound dressing agents

Osman

Amin

2020

Zanco J Med Sci

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Six groups of albino rats were used (6 rats in each group). Group M received Mebo ointment, Group Creceived Cica silver spray, Group K received Vitamin K injection, Group MK received Mebo ointment+vitamin K injection.Group CK received Cica silver spray +vitamin K Group, and Group N received no-treatment. The duration of the experiments was as 7, 14, and 21 days post wound surgery.The percentage of wound contraction was measured, and the blood serum was collected to test the level of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF). Results: Data presented in our study showed that the best wound contraction percentage (99%) was obtained by the MK treated rats compared to the control group. Similar results were obtained fromTGFβ and PDGF data in which MK group showed a significant increase in the levels of these growth factors. Conclusion:The wound healing process is supposed to be due to an increase of TGFβ, PDGF, and enhanced fibroblast proliferation and neovascularization of tissues.

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Comparative Study of the Therapeutic Effect of Panthenol Gel and Mebo Ointment on Metacarpal Wound Healing in Donkeys

Semieka

Ali

Khafar

et al. 2019

Journal of Equine Veterinary Science

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Moist Exposed Burn Ointment (MEBO) Dressing in Treatment of Equine Limb Distal Wounds

Cited by 3 publications

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Wound healing in immunocompromised dogs: A comparison between the healing effects of moist exposed burn ointment and honey

Wound healing in immunocompromised dogs: A comparison between the healing effects of moist exposed burn ointment and honey

The effect of vitamin K on the wound healing process in rat skin achieved by common wound dressing agents

Comparative Study of the Therapeutic Effect of Panthenol Gel and Mebo Ointment on Metacarpal Wound Healing in Donkeys

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