Mohs surgery for the treatment of lentigo maligna and lentigo maligna melanoma – a systematic review

Lentigo Maligna of the head and neck: A retrospective study assessing surgical excision margins in a South African population

“…MMS with frozen sections and immunohistochemistry staining has proven to be an effective treatment for melanoma in situ (including LM) as well as early invasive melanoma. 15 , 16 , 17 , 18 , 19 Recently published work showed MMS for early invasive melanoma to offer moderately improved overall survival compared to WLE. 15 Recurrence rates as low as 0% to 2% have been reported for LM treated with MMS using immunostaining.…”

“… 15 , 16 , 17 , 18 , 19 Recently published work showed MMS for early invasive melanoma to offer moderately improved overall survival compared to WLE. 15 Recurrence rates as low as 0% to 2% have been reported for LM treated with MMS using immunostaining. 15 , 20 …”

<p>Lentigo Maligna: Clinical Presentation and Appropriate Management</p>

“…A recent systematic review including 27 articles showed a 1.35% recurrence rate with MMS. 111 Another potential benefit of MMS is that LMM can be detected prior to reconstruction, allowing accurate sentinel lymph node biopsy (SNLB) prior to complex reconstructions that would otherwise compromise SNLB. In addition, some authors advise that the central tumor debulking specimen should be sent for formalin-fixed paraffin embedded sections, to detect possible invasion and eventual LMM upstaging.…”

Melanoma Recurrence after Mohs Micrographic Surgery with MART-1: A Systematic Review and Meta-analysis

“…To date, no systematic reviews have specifically examined the utilization of MART-1 staining in frozen sections for CMparticularly its effect on local recurrence. Sharma and colleagues 25 performed a broad systematic review to compare the local recurrence of MMS with that of traditional surgical techniques for lentigo maligna/lentigo maligna melanoma (LM/LMM) but only included 2 studies and failed to compare with MART-1.…”