Mohs' micrographic surgery for treatment of basal cell carcinoma of the face--results of a retrospective study and review of the literature

Smeets, N.W.J. Kelleners; Kuijpers, Daniëlle; Nelemans, Patty J.; Ostertag, J.U.; Verhaegh, M.E.J.M.; Krekels, Gertruud A. M.; Neumann, H. A. Martino

doi:10.1111/j.1365-2133.2004.06047.x

Cited by 240 publications

(237 citation statements)

References 40 publications

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“…The main advantage of such an approach is the one-stage tumor excision in clear margins, while the disadvantages are its being time-consuming and patient discomfort. A previous study (20) using a large patient cohort investigated the long-term outcome of Mohs micrographic surgery for basal cell carcinomas of the face. Results of that study demonstrated a 5-year recurrence rate of 4.5% for the lesions, 3.2% for primary tumors and 6.7% for recurrent ones.…”

Section: Frozen Section ---------------------------------------------mentioning

confidence: 99%

Study to determine whether intraoperative frozen section biopsy improves surgical treatment of non-melanoma skin cancer

Nicoletti

Brenta

Malovini

et al. 2012

Molecular and Clinical Oncology

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Abstract. Skin cancers are the most common types of cancer and their incidence has shown an increase of ~4 to 8% per year over the last 40 years. The majority of skin cancers (~97%) are non-melanoma skin cancers, mainly represented by basal cell (80%) and squamous cell carcinomas (20%). The use of intra-operative frozen section remains controversial in the surgical treatment of non-melanoma skin cancer, being commonly considered an optional tool, the reliability and effectiveness of which remain questionable. A large retrospective study was conducted to examine 670 surgical excisions of non-melanoma skin cancers of the head and neck in 481 patients over a period of nine years, between May, 2002 and December, 2011, at the Plastic and Reconstructive Surgery Unit of the University of Pavia, Salvatore Maugeri Research and Care Institute, Pavia, Italy. Results demonstrated the paradoxical ineffectiveness of an intra-operative frozen section biopsy in pursuing higher rates of radical excision in non-melanoma skin cancers. Nevertheless, a more detailed analysis on the use of frozen sections focusing on the various anatomical sites of the body demonstrated a reverse trend in the eyelids and canthi, where a higher success rate (87.50 vs. 69.77%) in the surgical treatment of non-melanoma skin cancers was obtained with the use of an intra-operative frozen section biopsy. Results of the present study suggested that intra-operative frozen section biopsy be routinely used in the surgical treatment of nonmelanoma skin tumors involving the eyelids and canthi.

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Section: Frozen Section ---------------------------------------------mentioning

confidence: 99%

Study to determine whether intraoperative frozen section biopsy improves surgical treatment of non-melanoma skin cancer

Nicoletti

Brenta

Malovini

et al. 2012

Molecular and Clinical Oncology

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“…The most frequently recurrences (70.3%-80.0%) are revealed as well as with after other methods of therapy of skin carcinomas; it ranges from 70.0 % to 82.4 % during the first year of monitoring [2,3,7,9]. A low percentage of facial carcinoma recurrences after laser treatment might be explained by the deeply penetrating laser energy [21] so that was possible to impact on the entire tumor mass.…”

Section: Discussionmentioning

confidence: 99%

“…However treatment of skin carcinomas localized on the face presents difficulties due to the complex anatomy of the area, which localized on the face approximately in 79.6-90.6% patients [3]. The use of above mentioned methods for the treatment of facial carcinoma results in tumor recurrence in 1.6-9.5% patients [3][4][5][6][7][8][9][10]. The progress in treatment of skin carcinoma has been achieved after laser radiation was introduced into practice [11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Morphological Factors in Evaluation of Efficacy of Facial Carcinoma Treatment by High-Energy Pulsed Neodymium Laser

Kg¹,

Ea²

2012

J Nucl Med Radiat Ther

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“…Primer lezyonda, 5 yıllık kür oranları %94 ile %99 arasında değişmektedir [26][27][28] . Mohs cerrahisinin başlıca endikasyonları 2 cm.den büyük, rekürren, yüksek risk içeren alanlarda BHK bulunması, periorbital, paranazal gibi geniş sınırlarla eksizyonun zor olduğu alanlarda BHK bulunması yer almaktadır 6 .…”

Section: Bhk Tedavi Seçenekleri Ve Güncel Yaklaşımlarunclassified

Current Advances in the Treatment of Basal Cell Carcinoma

Çalış¹,

Uzun²

2016

Acta Oncol Tur.

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ÖZETBazal hücreli karsinom, derinin en sık görülen malign tümörü olup insidansı giderek artmaktadır. Predispozan faktörler arasında en önemlisi güneş ışınlarına maruz kalmaktır. Bununla birlikte genetik hastalıklar, organ nakilleri ve immünsupresyon da bazal hücreli karsinom gelişimini tetiklemektedir. Oldukça nadir metastaz yapmasına rağmen lokal agresif seyreder. Ana tedavi şekli cerrahi olup cerrahiye aday olmayan hastalarda radyoterapi, kriyoterapi, kemoterapi ve hedgehog yolak inhibitörleri kullanılabilir. Bu derlemede bazal hücreli karsinomun tedavisi konusunda güncel gelişmeler tartışılmıştır.Anahtar Kelimeler: bazal hücreli karsinom, cerrahi, vismodegib ABSTRACT Basal cell carcinoma is the most commonly seen malignant tumor of the skin and its incidence is gradually increasing. Sun exposure is the single most important predisposing factor. In addition, genetic disorders, organ transplantations and immunesupression may trigger the development of basal cell carcinoma. Although it metastasizes rarely, its clinical course is local aggressive. The main treatment modality is surgery. In patients who are not candidates for surgery; radiotherapy, cryotherapy, chemotherapy and hedgehog pathway modulators can be used. In this review, current advances in the treatment of basal cell carcinoma is discussed.

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Mohs' micrographic surgery for treatment of basal cell carcinoma of the face--results of a retrospective study and review of the literature

Abstract: Based on the fact that MMS provides the lowest recurrence rates, it is the treatment of first choice for primary facial BCCs with an aggressive histopathological subtype and for recurrent BCCs in the face.

Cited by 240 publications

References 40 publications

Study to determine whether intraoperative frozen section biopsy improves surgical treatment of non-melanoma skin cancer

Study to determine whether intraoperative frozen section biopsy improves surgical treatment of non-melanoma skin cancer

Clinical and Morphological Factors in Evaluation of Efficacy of Facial Carcinoma Treatment by High-Energy Pulsed Neodymium Laser

Current Advances in the Treatment of Basal Cell Carcinoma

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