Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans

Ratner, Désirée; Thomas, Craig O.; Johnson, Timothy M.; Sondak, Vernon K.; Hamilton, Ted A.; Nelson, Bruce R.; Swanson, Neil A.; Garcia, Cédric; Clark, Robert E.; Grande, Donald J.

doi:10.1016/s0190-9622(97)70179-8

Cited by 234 publications

(84 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, in those five patients with recurrent tumours, the size would be underestimated by preceding attempts at clearance. Other studies have not observed a relationship of maximum tumour size to excision margin (Roses et al, 1986;Ratner et al, 1997). However, one report found tumours less than 2 cm could be safely excised by a 1.5 cm lateral margin (n=9), as opposed to those greater than 2 cm which needed 2.5 cm margin (n=11) (Parker and Zitelli, 1995).…”

Section: Discussionmentioning

confidence: 95%

“…The largest study incorporates grouped data of 50 patients from several centres (Ratner et al, 1997). Haycox et al (1997) reviewed the world-wide literature and found a mean recurrence rate of 2.4% from a total of 169 reported cases.…”

Section: Discussionmentioning

confidence: 99%

“…Haycox et al (1997) reviewed the world-wide literature and found a mean recurrence rate of 2.4% from a total of 169 reported cases. Although most series describe no recurrences the highest reported rate was two out of 24 cases (8.3%) (Dawes and Hanke, 1996), with two other groups each having had one recurrence in 15 (6.6%) and 50 (2%) patients followed-up (Gloster et al, 1996;Ratner et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…A lateral margin of 3 cm results in a local recurrence rate of 10 -20% (McPeak et al, 1967;Roses et al, 1986;Gloster et al, 1996) and at 4 cm a recurrence rate of 6% was found in 96 patients (Petoin et al, 1985). Of 58 cases, even a 10 cm excision width would not have cleared the tumour in two patients (Ratner et al, 1997).…”

mentioning

confidence: 98%

“…Micrographic controlled excision (MCE) of skin tumours allows examination of all surgical margins, and preliminary evidence for DFSP suggested this method to be effective (Mikhail and Lynn, 1978;Robinson, 1985;Parker and Zitelli, 1995). Results from subsequent series and retrospective studies show a consistently high rate for complete clearance in both primary and recurrent tumours (Hobbs et al, 1988;Dawes and Hanke, 1996;Gloster et al, 1996;Haycox et al, 1997;Ratner et al, 1997). Together these reports appear to indicate support for MCE as the most appropriate treatment of DFSP.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Dermatofibrosarcoma protuberans treated by micrographic surgery

Ah-Weng¹,

Marsden²,

Sanders³

et al. 2002

Br J Cancer

View full text Add to dashboard Cite

Dermatofibrosarcoma protuberans is an uncommon cutaneous tumour which rarely metastasises. However, local recurrence following apparently adequate surgical excision is well recognised, presumably as a result of sub-clinical contiguous growth, for which micrographically controlled excision would be a logical treatment. A retrospective study of all patients treated by micrographic surgery, from April 1995–March 2000, at a tertiary skin oncology centre. Twenty-one patients (11 males), age 14 to 71 years with dermatofibrosarcoma protuberans on the trunk (10 patients), groin (four), head and neck (four), and limbs (three) were treated. In 15 patients one micrographic layer cleared the tumour, and four were cleared with two layers. For one patient the second stage was completed by conventional excision guided by positive margins. Another patient with a multiply recurrent perineal dermatofibrosarcoma protuberans, not cleared in one area after two layers, died from a pulmonary embolus before total clearance could be achieved. There was no correlation between tumour size and lateral excision margin. No recurrence was observed during the follow-up, from 21 to 80 months, median 47 months. The study provides further support for micrographic surgery as the treatment of choice for dermatofibrosarcoma protuberans. British Journal of Cancer (2002) 87 , 1386–1389. doi: 10.1038/sj.bjc.6600643 www.bjcancer.com © 2002 Cancer Research UK

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

mentioning

confidence: 99%

See 3 more Smart Citations

Dermatofibrosarcoma protuberans treated by micrographic surgery

Ah-Weng¹,

Marsden²,

Sanders³

et al. 2002

Br J Cancer

View full text Add to dashboard Cite

show abstract

Congenital Dermatofibrosarcoma Protuberans

et al. 2003

View full text Add to dashboard Cite

A Clinical, Histologic, and Molecular Study of 9 Cases of Congenital Dermatofibrosarcoma Protuberans

Maire

Fraïtag²,

Galmiche³

et al. 2007

Arch Dermatol

View full text Add to dashboard Cite

Background:The diagnosis of dermatofibrosarcoma protuberans (DFSP) in childhood is often difficult because of the deceptive appearance of the lesions. Little is known about congenital DFSP, the frequency of which is probably underestimated because the initial lesion may pass unnoticed.Observations: We studied 9 DFSP congenital cases (8 plaques and 1 nodule) initially suspected to be benign lesions. The first biopsies or excisions were performed after a delay of 5½ months to 15 years. All cases were CD34ϩ. Histologic patterns were similar to the DFSP adult classic pattern in 4 cases. One case was a Bednar tumor. The histologic diagnosis of the 4 remaining cases was difficult. The collagen, type I, ␣ 1-platelet-derived growth factor ␤ fusion gene (COL1A1-PDGFB) was detected by means of reverse transcriptase-polymerase chain reaction or fluorescence in situ hybridization.Conclusions: All cases of congenital DFSP were difficult to identify clinically. The diagnosis was suspected by means of histologic and immunohistochemical evaluation and was confirmed using molecular analyses. This study illustrates the difficulties and pitfalls of the recognition of congenital DFSP and emphasizes the value of immunohistochemical study with anti-CD34 and complementary molecular analysis for all cutaneous spindle cell tumors and plaques in neonates and infants.

show abstract

Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans

Cited by 234 publications

References 26 publications

Dermatofibrosarcoma protuberans treated by micrographic surgery

Dermatofibrosarcoma protuberans treated by micrographic surgery

Congenital Dermatofibrosarcoma Protuberans

A Clinical, Histologic, and Molecular Study of 9 Cases of Congenital Dermatofibrosarcoma Protuberans

Contact Info

Product

Resources

About