Mohs micrographic surgery combined local flaps in treatment of EMPD: A retrospective case

Li, Lili; Wang, Chen; Wei, Minghai; Huang, Qiuxia; Wei, Lan; Pan, Nannan; Xie, Zhi

doi:10.1111/dth.12663

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Among the 81 full-text review articles, 27 studies met the inclusion criteria. 8,9,15,21,26–47 A PRISMA flow chart is found in Supplemental Digital Content 3 , Figure S7, http://links.lww.com/DSS/B162.…”

Section: Resultsmentioning

confidence: 99%

Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis

Kim

Campbell

Brewer

2022

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Section: Resultsmentioning

confidence: 99%

Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis

Kim

Campbell

Brewer

2022

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Network meta-analysis of treatments for perineal extramammary paget’s disease: Focusing on performance of recurrence prevention

Yuan,

Xue,

Cao

2023

PLoS ONE

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Introduction Perineal extramammary paget’s disease (EMPD) is characterized with high recurrence rate. Although numerous therapeutic measures for this disease have been reported so far, it is unknown whether there is significant difference in their recurrence-preventing efficiency. This study aims to compare the recurrence outcomes of reported perineal EMPD treatments. Methods We searched public databases of for published studies concerning perineal EMPD treatments. After screening by inclusion and exclusion criteria, we extracted the data relevant to recurrence rate, and conducted network meta-analysis (NMA) by using Bayesian random-effects approach. Results Our analysis included 29 previous studies (involving both male and female patients) and 11 treatment designs which are wide local excision (WLE), local excision (LE), Mohs micrographic surgery (MMS), radiotherapy (RT), radical vulvectomy (RV), photodynamic therapy (PDT), lasers (LS), imiquimod, and WLE+RT, WLE+PDT, WLE+LS. Comparing with WLE, the MMS showed significant advantage in reducing recurrence [OR: 0.18 (0.03–0.87)], while none of the rest treatments has statistically significant results. After removing outlier studies, MMS still has the significant advantages [OR: 0.35 (0.11–0.82)], and LE turned to be the treatment with worst performance [OR: 13 (2.50–110)]. Covariance analysis of follow-up length, gender differences, and lesion locations indicated only short follow-up time could affect the recurrence statistics, which tend to conceal the real differences. Funnel plot demonstrated there is no significant small study effect. Conclusion MMS has the best performance on reducing perineal EMPD recurrence, while LE exhibits the worst capability in such regard. Recurrence-preventing abilities of other treatments have no significant difference between each other.

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Mohs micrographic surgery combined local flaps in treatment of EMPD: A retrospective case

Cited by 2 publications

References 20 publications

Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis

Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis

Network meta-analysis of treatments for perineal extramammary paget’s disease: Focusing on performance of recurrence prevention

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