Mogoltacin enhances vincristine cytotoxicity in human transitional cell carcinoma (TCC) cell line

Rassouli, Fatemeh Behnam; Matin, Maryam Moghaddam; Iranshahi, Mehrdad; Bahrami, Ahmad Reza; Neshati, Vajiheh; Mollazadeh, Samaneh; Neshati, Zeinab

doi:10.1016/j.phymed.2008.06.011

Cited by 24 publications

(12 citation statements)

References 26 publications

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“…The probable mechanism of feselol action could be its interaction with and inhibition of the function of the MRP2. Furthermore, we have previously shown that, besides increasing the cytotoxic effects of anticancer agents Behnam Rassouli et al, 2009;Rassouli et al, 2011a;Mollazadeh et al, 2010), terpenoid derivatives from Ferula species show cytotoxic effects in vitro (Rassouli et al, 2011b). However, more research is needed to test whether feselol has the same effects on other drug-resistant cells and also to analyse its mode of action.…”

Section: Discussionmentioning

confidence: 99%

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Feselol Enhances the Cytotoxicity and DNA Damage Induced by Cisplatin in 5637 Cells

Mollazadeh

Matin

Bahrami

et al. 2011

Zeitschrift Für Naturforschung C

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Transitional cell carcinoma (TCC), which is the most common type of bladder cancer, shows resistance to chemotherapeutic agents due to the overexpression of drug effl ux pumps. In this study, the effects of feselol, a sesquiterpene coumarin extracted from Ferula badrakema, on cisplatin cytotoxicity were investigated in 5637 cells, a TCC subline. Cell viability and DNA lesion were evaluated by thiazolyl blue tetrazolium bromide and comet assays, respectively. Feselol had no signifi cant cytotoxic effect in 5637 cells but at 32 μg/mL it increased the cytotoxicity of 1 μg/mL cisplatin by 37% after 24 h. Furthermore, the comet assay revealed that DNA damage induced by cisplatin in 5637 cells is enhanced by 31% when used in combination with feselol. Therefore, feselol might be considered as an effective reversal agent for future in vivo and clinical studies.

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Section: Discussionmentioning

confidence: 99%

“…Sesquiterpene coumarins of the drimane type (diportlandin, conferone, mogoltacin, and feselol, Fig. 1) can increase the accumulation and effectiveness of several anticancer agents (Madureira et al, 2004;Barthomeuf et al, 2006;Neshati et al, 2009;Behnam Rassouli et al, 2009;Rassouli et al, 2011a;Mollazadeh et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Feselol Enhances the Cytotoxicity and DNA Damage Induced by Cisplatin in 5637 Cells

Mollazadeh

Matin

Bahrami

et al. 2011

Zeitschrift Für Naturforschung C

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“…Sesquiterpene coumarins have also been shown to enhance the cytotoxicity of chemotherapeutic agents. For example, mogoltacin, conferone and feselol, sesquiterpene coumarins from Ferula badrakema, can significantly enhance the cytotoxicity of vincristine in transitional cell carcinoma cells [143][144][145]. Other alternative approaches to target P-glycoprotein-mediated drug resistance could involve the development of agents to interfere with any one of the regulatory steps in expression of P-glycoprotein: transcription, mRNA turnover, translation, protein processing, and turnover [53,146].…”

Section: Elimination Therapymentioning

confidence: 99%

Cancer stem cells and cancer therapy

2011

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Cancer stem cells (CSCs) are a subpopulation of tumour cells that possess the stem cell properties of self-renewal and differentiation. Stem cells might be the target cells responsible for malignant transformation, and tumour formation may be a disorder of stem cell self-renewal pathway. Epigenetic alterations and mutations of genes involved in signal transmissions may promote the formation of CSCs. These cells have been identified in many solid tumours including breast, brain, lung, prostate, testis, ovary, colon, skin, liver, and also in acute myeloid leukaemia. The CSC theory clarifies not only the issue of tumour initiation, development, metastasis and relapse, but also the ineffectiveness of conventional cancer therapies. Treatments directed against the bulk of the cancer cells may produce striking responses but they are unlikely to result in long-term remissions if the rare CSCs are not targeted. In this review, we consider the properties of CSCs and possible strategies for controlling the viability and tumourigenecity of these cells, including therapeutic models for selective elimination of CSCs and induction of their proper differentiation.

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“…Ferula species from the family Apiaceae are rich sources of biologically active natural products including sulphur-containing compounds (Mozaffarian, 1996;Iranshahi et al, 2003a;Iranshahi et al, 2006;Iranshahi, 2012), sesquiterpene coumarins (SCs) (Iranshahi et al, 2004;Iranshahi et al, 2010a;Iranshahi et al, 2010b;Esmail Nazari and Iranshahi, 2011;Kasaian et al, 2014a), and sesquiterpenes (Iranshahi et al, 2003b;Iranshahi et al, 2008;Kasaian et al, 2014b). Some studies showed that SCs were able to enhance the cytotoxicity of * anticancer compounds (Behnam Rassouli et al, 2009;Neshati et al, 2009;Rassouli et al, 2011). Recently, Iranshahi et al (2014) reported that feselol, conferone, and mogoltacin, drimane-type SCs from Ferula gummosa fruits, enhanced doxorubicin uptake in doxorubicinresistant human breast cancer cell line (Iranshahi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Modulation of Multidrug Resistance Protein 2 Efflux in the Cisplatin Resistance Human Ovarian Carcinoma Cells A2780/RCIS by Sesquiterpene Coumarins

et al. 2015

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Recent in vitro studies showed that sesquiterpene coumarins (SCs) can be used as chemosensitizers. In this study, 14 SCs were isolated and purified from roots of four Ferula species and their structures were elucidated by spectroscopic methods. The purified SCs were evaluated for multidrug resistance (MDR) reversal properties in A2780/RCIS cells (cisplatin-resistant derivatives of the human ovarian carcinoma cell line A2780P). Among the tested compounds, mogoltacin, mogoltadone, farnesiferol A, farnesiferol B, farnesiferol C, lehmferin, conferdione, and samarcandin showed significant MDR reversing effects. The combination of nontoxic concentrations of SCs (20 μM) with cisplatin enhanced cisplatin cytotoxicity on A2780/RCIS cells significantly. Flow cytometric efflux assay confirmed that the intracellular accumulation of 5-carboxyfluorescein diacetate (5-CFDA) was significantly increased in A2780/RCIS cells when treated with SCs. Our findings revealed that conferdione and samarcandin possessed the highest inhibitory effects on multidrug resistance-associated protein 2 pump efflux, and therefore, these compounds could be considered as lead scaffolds for further structure modifications.

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Mogoltacin enhances vincristine cytotoxicity in human transitional cell carcinoma (TCC) cell line

Cited by 24 publications

References 26 publications

Feselol Enhances the Cytotoxicity and DNA Damage Induced by Cisplatin in 5637 Cells

Feselol Enhances the Cytotoxicity and DNA Damage Induced by Cisplatin in 5637 Cells

Cancer stem cells and cancer therapy

Modulation of Multidrug Resistance Protein 2 Efflux in the Cisplatin Resistance Human Ovarian Carcinoma Cells A2780/RCIS by Sesquiterpene Coumarins

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