MOG-IgG-associated disorder and systemic lupus erythematosus disease: Systematic review

Abstract

Introduction Myelin oligodendrocyte glycoprotein (MOG) is a nervous system protein expressed by oligodendrocytes to constitute the myelin sheath. Autoantibodies against MOG have been widely described in neurological and autoimmune diseases such as MOG-IgG-associated disorder (MOGAD). Although underlying mechanisms have not yet been understood, an overlap of MOGAD and Systemic Lupus Erythematosus (SLE) has been shown in the literature. Objectives The aim of this systematic review was to assess the possible correlations between MOGAD and SLE based on reported features found in the literature that support the association of the two. Methods A keyword-based literature search was conducted, applying a ten-year filter and using the following key-words: “MOG autoantibody-associated disease and Systemic Lupus Erythematosus”; “MOG and Systemic Lupus Erythematosus” “Anti-MOG and Lupus”; “MOG and SLE”; “MOG and LUPUS” on MEDLINE/PUBMED, ScienceDirect, SciELO, LILACS and Cochrane; and “MOG antibody-associated disease and SLE” on Google Scholar. Results Eleven publications reporting on the MOGAD and SLE correlation were included in qualitative synthesis: animal experiment (1), cross-sectional (3), prospective (2), retrospective (1), non-systematic review (3), and case report (1) studies. Conclusion Not much is known about the connection between MOG-IgG-associated disorder and SLE. Unfortunately, only observational studies have been conducted in humans so far, providing us with limited data. While MOGAD features have been reported to develop in SLE patients, this is not an universal finding. In fact, many different issues impair these results, making it difficult to match the findings of different studies.

Overlap syndrome of anti-aquaporin-4 positive neuromyelitis optica spectrum disorder and systemic lupus erythematosus: A systematic review of individual patient data

“…6 Besides NMOSD, myelitis in lupus can be seen primarily due to the disease, co-existing anti-phospholipid antibody syndrome (APS), myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOGAD), multiple sclerosis (MS), and acute disseminated encephalomyelitis (ADEM). 9,23 We noted a relatively higher acute cerebral syndrome (10.9%) in the core manifestations in NMOSD in our review, which can be present in SLE, but the reported prevalence in NMOSD is 3.1%-5.8%. 24 This might be difficult to differentiate threadbare whether SLE or NMOSD is driving the pathophysiology in these cases of cerebral involvement.…”

Systemic association of myelin oligodendrocyte glycoprotein antibody disease: A systematic review of literature

“…Lower Sema3A levels also have a share in the pathogenesis of SLE and other autoimmune diseases, and disease activity inversely correlates with its serum levels. Interestingly enough, the Sema3A receptor, neuropilin‐1 (NRP‐1), attenuates autoreactivity of MOG‐induced EAE, while the lack of this receptor aggravates it 36 …”

A Case of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Peripheral Neuropathy With Positive Anti-Myelin Oligodendrocyte (MOG) Antibodies

“…Even though there were no CNS manifestations of MOGAD, there have been several case reports of MOGAD associated with peripheral neuropathy [ 5 ] and Giant Cell Arteritis (GCA), another medium vessel vasculitis which is why it was part of the differential diagnosis. Additionally, MOGAD has been associated with autoimmune conditions like Systemic Lupus Erythematosus (SLE) and Neuromyelitis Optica spectrum disorder (NMOSD) [ 11 ] which opened up further discussions. It is important to note however, there are reports of the possibility of a false positive test for MOG-IgG due to cross-reactivity with other autoantibodies [ 12 ].…”