MOF-Mediated Synthesis of CuO/CeO2 Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7)

Abstract

A copper oxide/cerium oxide nanocomposite (CuO/CeO2, NC) was synthesized via a novel method using a metal–organic framework as a precursor. This nanomaterial was characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic light scattering size analysis (DLS), and zeta potential. The PXRD showed the successful synthesis of the CuO/CeO2 NC, in which the 2theta values of 35.55° (d = 2.52 Å, 100%) and 38.73° (d = 2.32 Å, 96%) revealed the existence of copper (II) oxide. FTIR analysis showed the CeO2, hydroxyl groups, absorbed water, and some residual peaks. The solid phase analysis by FESEM and TEM images showed mean particle sizes of 49.18 ± 24.50 nm and 30.58 ± 26.40 nm, respectively, which were comparable with crystallite size (38.4 nm) obtained from PXRD, but it appears the CuO/CeO2 NC was not evenly distributed and in some areas, showed it was highly agglomerated. The hydrodynamic size (750.5 nm) also showed the agglomeration of the CuO/CeO2 NCs in the solution, which had a negatively charged surface. The CuO/CeO2 NCs showed anti-proliferative activity against human breast cancer cell line (MCF-7) in a dose- and time-dependence way, while affecting normal cells less significantly.

RETRACTED ARTICLE: In vitro antioxidant, anticancer, anti-inflammatory, anti-diabetic and anti-Alzheimer potentials of innovative macroalgae bio-capped silver nanoparticles

“…Consequently, the plant-and alga-originated particles such as flavonoids, tannins, polyphenols, alkaloids, and polysaccharides are highly accepted for their wide-ranging biological roles and have an immense therapeutic possibility in nano-medicines for various types of diseases Watkins et al 2015;Saratale et al 2018b;Barani et al 2021;Javad Farhangi et al 2021). So, the biosynthesis of NPs from plant and algal extracts is currently the greatest manipulated technique because it is eco-friendly, obtainable, cost-saving, biocompatible and safe (Pillai et al 2020;Mahmoud et al 2020Mahmoud et al , 2021Barani et al 2021;Hassanisaadi et al 2021;Es-Haghi et al 2021;Mohammadzadeh et al 2022;Hassanisaadi et al 2022).…”

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

“…Nanomedicine has led to the development of a variety of nanoscale therapeutics and diagnostics to treat a variety of diseases, specifically cancer [6,14,15,17,18,[36][37][38][39][40][41][42][43][44][45][46]. This fact is broadly exploited in the field of DNA nanotechnology [47].…”

“…Recent approaches in nanomedicine have prompted the development of effective theranostic platforms for a myriad of biological and biomedical applications [2]. Nanomaterials (i.e., niosomes [3], polymer-based nanocapsules [4], nanoparticles (NPs) [5][6][7][8], metal nanocages [9], nanocomposites [10], nanoliposomes [11], and engineered nanohydrogels [12]), with highly controlled geometry and physic-chemical properties, have been introduced as promising tools for recognizing cancer tissues and also serve as novel drug delivery systems (DDSs) to achieve active targeting [2,[13][14][15][16][17][18][19][20][21]. It is now believed that nanotechnology can purposefully improve the clinical outcome of cancer therapies through improving the tolerability of the efficacy of novel drugs [22] or delivering proteins, DNA, RNA, and various types of jected synergistic tetravalent RNA-NPs into the tail-vein of mice.…”

Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma

“…The gold inertness and its nontoxic nature are of great use in the design of new active nanomaterials and nanocomposites for biomedical applications [31][32][33][34]. The factors that can be crucial in determining the final anticancer properties can be the size, shape, and ratio of the components [35,36]. Gold nanoparticles' toxicity is directly proportional to the size of nanoparticles.…”