MOF‐Derived Double‐Layer Hollow Nanoparticles with Oxygen Generation Ability for Multimodal Imaging‐Guided Sonodynamic Therapy

Abstract

The high reactive oxygen species (ROS) generation ability and simple construction of sonosensitizer systems remain challenging in sonodynamic therapy against the hypoxic tumor. In this work, we rationally prepared MOF‐derived double‐layer hollow manganese silicate nanoparticle (DHMS) with highly effective ROS yield under ultrasound irradiation for multimodal imaging‐guided sonodynamic therapy (SDT). The presence of Mn in DHMS increased ROS generation efficiency because it could be oxidized by holes to improve the electron–hole separation. Moreover, DHMS could produce oxygen in the tumor microenvironment, which helps overcome the hypoxia of the solid tumor and thus enhance the treatment efficiency. In vivo experiments demonstrated efficient tumor inhibition in DHMS‐mediated SDT guided by ultrasound and magnetic resonance imaging. This work presents a MOF‐derived nanoparticle with sonosensitive and oxygen generating ability, which provides a promising strategy for tumor hypoxia in SDT.

Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

“…H1299 cells were treated by various concentrations of SnNSs@PEG followed by the US irradiation for 3 min (1 min per cycle, 3 cycles). The results showed that no cell viability decrease of the US only group was observed (Figure 4 c; Figure S12a, SI), indicating the US exposure was harmless to cells and is a biocompatible treatment modality for cancer therapy [54–58] . In contrast, the viabilities of H1299 cells were 85 %, 72 %, 53 %, and 28 % when the SnNSs@PEG concentrations were 25, 50, 100, and 200 μg mL −1 , respectively (Figure 4 c; Figure S12a, SI).…”

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

“…developed another MOF‐derived sonosensitizer, the double‐layer hollow manganese silicate nanoparticle (DHMS) by the in situ growth of Mn 2+ using ZIF‐8 as a template (Figure 7E). [ 62 ] As a result, DHMS was shown to generate excess 1 O 2 and •OH due to the presence of the Mn element, which could be oxidized under US irradiation by produced holes to effectively improve the separation efficiency of electrons and holes. Besides, DHMS could also catalyze endogenous hydrogen peroxide (H 2 O 2 ) for generation of O 2 to alleviate tumor hypoxia and further increase the efficiency of ROS.…”

“…Reproduced with permission. [ 62 ] Copyright 2020, Wiley‐VCH. F) BaTiO 3 ‐mediated piezoelectric therapy triggered by ultrasonic vibration.…”

Transitional Metal‐Based Noncatalytic Medicine for Tumor Therapy

“…In another design, a novel MOF-derived double-layer hollow manganese silicate nanoparticles (DHMS) sonosensitizer with efficient oxygen yield were constructed to generate ROS effectively under US irradiation for multimodal imaging-guided SDT (Figure 7f). [41] On the one hand, DHMS was capable of producing O 2 through reaction with endogenous H 2 O 2 , providing sufficient reactant for US-triggered 1 O 2 yielding (Figure 7g). On the other hand, the transition metal Mn in DHMS could be oxidized by US-induced holes, thus effectively improving the electronhole separation for •OH generation from H 2 O (Figure 7h).…”