MOF catalysis meets biochemistry: molecular insights from the hydrolytic activity of MOFs towards biomolecules

Abstract

Performing reactions under physiologically relevant conditions often challenges the catalysts’ robustness, reactivity and recyclability. Widely regarded as stable and versatile materials, metal-organic frameworks (MOFs) are an emerging platform for the...

Reactivity of metal–oxo clusters towards biomolecules: from discrete polyoxometalates to metal–organic frameworks

“…45,[50][51][52][257][258][259] Moreover, MOFs have been shown to catalyze a wide range of biomolecular transformations as has been recently described in detail in a recent review. 59 Therefore, this section will only focus on the reactivity towards biomolecules of MOFs based on MOCs, especially to draw comparisons with the studies on discrete clusters. Other hybrid materials based on MOCs will also be discussed where relevant to highlight where the limits of MOFs lie and where improvements are still needed.…”

Exploring the Reactivity of Polyoxometalates toward Proteins: From Interactions to Mechanistic Insights

“…Finally, the reactivity between POMs and proteins discussed herein has already inspired research on other promising reactivity avenues, which have been emerging in recent years. For example, some of these results are being translated into the use of other types of metal-oxo clusters as discrete units, or in MOFs, for the hydrolysis of proteins, and may be extended to other biological systems. ,, Additionally, metal-oxo clusters in general have been shown to serve as excellent and highly robust catalysts not only for the cleavage of amide bonds, but also for their formation, which is instrumental for the synthesis of certain pharmaceuticals, polymers and other important synthetic compounds. − Therefore, the study of the reactivity between POMs and proteins addresses underexplored areas of bioinorganic chemistry, and paves the way toward varied innovative solutions across chemistry.…”

Advances and Applications of Metal‐Organic Frameworks (MOFs) in Emerging Technologies: A Comprehensive Review

“…As a family of porous materials, MOFs are playing a crucial role in the development of artificial enzymes that operate in biological systems which are reviewed in detail by Simms and co-workers. [128] A bifunctional photocatalyst MOF, Zr-OTf-EY (EY = Eosin Y dye) wherein EY acts as a Lewis acid on metal cluster nodes in MOF underwent cross-coupling catalytic reaction of C-H compounds with electron-deficient alkenes or azodicarboxylate, giving rise to C-C and C-N products with a TON (Turn-over number) of 1980 (Figure 4a). [129] The proximity between photoactive EY and nodes of MOF increased the catalytic performance ≈ 400 times.…”

“…As a family of porous materials, MOFs are playing a crucial role in the development of artificial enzymes that operate in biological systems which are reviewed in detail by Simms and co‐workers. [ 128 ]…”