Moebius syndrome—Case report

Gheorghe, Dan Cristian; Stanciu, Adina Elena; Zamfir-Chiru-Anton, Adina; Oprea, Doru; Epure, Veronica

doi:10.1002/ccr3.6715

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…In the neonatal period, the main focus of Moebius syndrome treatment is to restore normal breathing and feeding function [ 2 ]. Patients with difficulty swallowing or with tongue movements may require feeding tubes in infancy.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Social Determinants of Health in the Care of Moebius Syndrome: A Case Report

Schwartz,

Limonta,

Goodman

et al. 2023

Cureus

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Moebius syndrome is a rare congenital disorder characterized by nonprogressive uni- or bilateral abducens nerve (VI) and facial nerve (VII) palsy. Other cranial nerves (CN) such as CN III, IV, and IX-XII may be involved leading to varied presentations. Speech development, communication, and psychomotor complications are common. Given the complexity of the disease, patients require an individualized, multidisciplinary care plan involving many medical specialists. Accessing this level of care without insurance poses seemingly insurmountable challenges and places immense financial strain on both patients with Moebius syndrome and their families. Physicians must advocate for patients with Moebius syndrome and be knowledgeable about the community resources available to them such as non-profit organizations. This report presents a case of Moebius syndrome in an uninsured, immigrant, 13-year-old male and the barriers to providing him with adequate care.

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Section: Discussionmentioning

confidence: 99%

“…Prevalence is estimated to be 1/250,000 live births [ 1 ]. Involvement of other cranial nerves (III, IV, and IX-XII) may also occur leading to a variety of craniofacial, odontological, orthopedic, and ophthalmological presentations [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Social Determinants of Health in the Care of Moebius Syndrome: A Case Report

Schwartz,

Limonta,

Goodman

et al. 2023

Cureus

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“…Classic MS is characterized by bilateral or unilateral paralysis of cranial nerves VI and VII; however, it can also be associated with other anomalies or syndromes, such as Kallman, Hanhart, or Poland syndrome. In some cases, patients may have a more extensive involvement affection the cranial nerves: Oculomotor (III), pathetic (IV), trigeminal (V), glossopharyngeal (IX), vagus (X), and hypoglossal (XII) [ 7 ]. The most frequent clinical manifestations of the oral and maxillofacial region included inexpressive facies (lack of smile and facial expression), low implantation of the pinna, and deformity of the ears with hearing loss, micrognathia, microstomia, cleft palate, bifid uvula, occlusal problems [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Oral findings and comprehensive dental management of Moebius syndrome: a systematic review

Alarcón-Sánchez,

Romero-Servin,

Yessayan

et al. 2024

BMC Oral Health

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Background Moebius syndrome (MS) is a rare, non-progressive, neuromuscular, congenic disease involving the oral maxillofacial region. The present study aimed to describe the oral and extraoral findings in MS patients and their comprehensive dental management. Methods A digital search was carried out in PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar, restricted to articles in English from Jan 01, 2000, to Apr 02, 2023, following PRISMA guidelines. The methodological quality of the studies was evaluated following the JBI guidelines. Qualitative analysis was carried out on the overall result, extraoral and intraoral manifestations, considering dental management as appropriate. Results Twenty-three studies were included, and a total of 124 cases of patients with MS were analyzed. The 82% of patients with MS were younger than 15 years of age. The most frequent extraoral manifestations were blinking and visual problems (78,22%), malformations of the upper and lower limbs (58,22%), bilateral facial paralysis (12,90%), lack of facial expression (12.09%), and unilateral facial paralysis (6,45%). On the other hand, the most frequent oral manifestations were tongue deformities (78,22%), micrognathia (37,90%), labial incompetence (36,29%), cleft palate (22,87%), gothic palate (16,12%), microstomia (15,32%), anterior open bite (15,32%), dental caries (8,87%), and periodontal disease (8,06%). The majority of MS patients were treated by pediatric dentistry (60,86%), using a surgical approach (56,52%), and orthodontic and orthopedic maxillary (43,47%) followed by restorative (39,13%), and periodontal treatments (21,73%). Conclusions This systematic review demonstrates that patients with MS present a wide variety of oral and extraoral manifestations, for which dental treatments are planned and tailored to each patient in accordance with oral manifestations. These treatments encompass problem resolution and oral health maintenance, incorporating recent techniques in managing and treating patients with MS.

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Moebius syndrome—Case report

Cited by 2 publications

References 7 publications

Impact of Social Determinants of Health in the Care of Moebius Syndrome: A Case Report

Impact of Social Determinants of Health in the Care of Moebius Syndrome: A Case Report

Oral findings and comprehensive dental management of Moebius syndrome: a systematic review

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