This paper focuses on moe-phobia, sexuality, and psychological resistance toward manga-like virtual agents. Moe-phobia is psychological disgust to sexual manga-like virtual agents. In a prior study, it was reported that the agents’ appearance and context had an interaction effect on moe-phobia in movies. This paper has two aims: to verify whether the interaction between appearance and context shown in previous studies is also observed in an experiment using still pictures, and to investigate the correlation between the degree to which participants exhibit moe-phobia and their political leanings. I conducted an experiment with three factors and two conditions. The factors were the agents’ appearance (swimsuit, white coat), context (pool, science museum), and the participants’ gender. The participants answered questions related to the agents’ sexuality and appropriateness perceived as well as a scale of conservative tendency. As a result, an interaction between appearance and context was observed. Also, the relationship between moe-phobia and conservative tendency was limited. These findings provide new insights into creating sexual advertisements and discussing moe-phobia.