Modulatory role of vanadium on trace element profile in diethylnitrosamine-induced rat hepatocarcinogenesis

Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers

“…Even though vanadium may participate in Fenton-like reactions [9], together with the proposed mechanisms of vanadate action that involves its bioreduction and ROS production [15,18,19,40], our results point out to a depression in the overall rate of ROS production. This observation is in good agreement with previous reports showing that vanadate supplementation diminished oxidative stress in certain experimental conditions, such as in rat-induced hepatocarcinogenesis [23] and in rat diabetic tissues [41]. Regarding superoxide anion radical production in mitochondrial fraction, once again it was observed that metavanadate and decavanadate promoted opposite effects.…”

“…present, it has been shown that vanadate can attenuate hepatic lipid peroxidation in induced hepatocarcinogenesis [23] and in 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis [42] and that vanadate does not change lipid peroxidation of control subjects [42]. We did not obtain any depression in lipid peroxidation in hepatic tissue after vanadate administration, even though there is maintenance of lipid peroxidation propagation until 12 h in decavanadate-administered individuals.…”

“…Since GSH was found to be involved in vanadate bioreduction [10][11][12][13][14][15], the levels of GSH should be affected when vanadate is administered. Indeed, it has been reported that the GSH pool is enhanced in the presence of vanadate [23,39].…”

“…Moreover, vanadium toxicological effects in several cell types have been related with ROS production [16][17][18][19]. Nevertheless, vanadium was recently reviewed as ''an element of atypical biological significance'' [20], due to insulin mimetic properties of vanadium [16,21,22] and to the preventive effects of vanadium against animal carcinogens [23][24][25][26].…”

In Vitro Radiation Induced Alterations in Heavy Metals and Metallothionein content in Plantago ovata Forsk

“…For PIXE analysis, these were then finally ground into powder and mixed thoroughly with extrapure graphite in a desired ratio (60:40). For each plant part, about 150 mg was palletized using a pelletizer and, using a 10-mm die, made into 1-mm-thick pellets according to the standardized protocol for thick target preparation of biological samples [36].…”