Modulatory Role of Vaginal-Isolated Lactococcus lactis on the Expression of miR-21, miR-200b, and TLR-4 in CAOV-4 Cells and In Silico Revalidation

Saadat, Yalda Rahbar; Pourseif, Mohammad M.; Vahed, Sepideh Zununi; Omidi, Yadollah; Barar, Jaleh

doi:10.1007/s12602-019-09596-9

Cited by 19 publications

(12 citation statements)

References 47 publications

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“…For instance, lung cancer microbiota is enriched in Proteobacteria and is more diverse in adenocarcinoma and squamous cell carcinoma, particularly in males and heavier smokers [91]. On the other hand, numerous miRNAs are differently expressed in lung disease [92,93], and miRNA-21 is overexpressed in lung cancer [94], and it is well known that numerous elements of the microbiota such as Bacteroides, Lactococcus lactis and Fusobacterium nucleatum are able to modify the expression of this miRNA [31,43,50].…”

Section: Discussionmentioning

confidence: 99%

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Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities

Allegra

Musolino

Tonacci

et al. 2020

Cancers

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The human microbiota is made up of the fungi, bacteria, protozoa and viruses cohabiting within the human body. An altered microbiota can provoke diseases such as cancer. The mechanisms by which a modified microbiota can intervene in the onset and progression of neoplastic diseases are manifold. For instance, these include the effects on the immune system and the onset of obesity. A different mechanism seems to be constituted by the continuous and bidirectional relationships existing between microbiota and miRNAs. MiRNAs emerged as a novel group of small endogenous non-coding RNAs from that control gene expression. Several works seem to confirm the presence of a close connection between microbiota and miRNAs. Although the main literature data concern the correlations between microbiota, miRNAs and colon cancer, several researches have revealed the presence of connections with other types of tumour, including the ovarian tumour, cervical carcinoma, hepatic carcinoma, neoplastic pathologies of the central nervous system and the possible implication of the microbiota-miRNAs system on the response to the treatment of neoplastic pathologies. In this review, we summarise the physiological and pathological functions of the microbiota on cancer onset by governing miRNA production. A better knowledge of the bidirectional relationships existing between microbiota and miRNAs could provide new markers for the diagnosis, staging and monitoring of cancer and seems to be a promising approach for antagomir-guided approaches as therapeutic agents.

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Section: Discussionmentioning

confidence: 99%

“…Results revealed that L. lactis downregulates TLR-4, miR-21 and miR-200b expression, which relates with an increase of apoptosis. Numerous targets, including miRNA-21-5p-MKNK2, miRNA-17-5p-BCL2 and miRNA-129-5p-CDK6 were recognised, while CCNB1 and VEGFA were discovered as the hub proteins in the miRNA-target network [31].…”

Section: Microbiota and Ovarian Cancermentioning

confidence: 99%

Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities

Allegra

Musolino

Tonacci

et al. 2020

Cancers

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“…Moreover, exfoliated cells of the cervix that are associated with cancer progression present dysregulated miR-375, miR-125, and miR-34a [120]. It is found that vaginal-isolated Lactobacillus lactis leads to the downregulation of TLR-4, miR-200b, and miR-21, which is associated with apoptosis induction [121]. Also, it is observed that the probiotic Escherichia coli Nissle 1917 restores the expression levels of some miRNAs, including miR-143, miR-155, [123].…”

Section: Effects Of Probiotics On the Therapeutic Targets Of Cervicalmentioning

confidence: 99%

Anti-tumor activities of probiotics in cervical cancer

et al. 2020

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Cervical cancer is considered as an important malignancy among women worldwide. Currently-used treatments of cervical cancer are reported to be cytotoxic for patients. Moreover, these therapies have shown some side effects which can negatively affect the lives of women suffering from this cancer. Therefore, there is need for anti-tumor agents that are less toxic than common therapeutic drugs. Besides, applying agents for preventing or reducing the side effects of cervical cancer therapies can be effective in improving the life quality of cervical cancer patients. Studies have shown that probiotics have several effects on biological processes. One of the most prominent aspects in which probiotics play a role is in the field of cancer. There are multiple studies which have focused on the functions of probiotics in diagnosis, prevention, or treatment of cancer. Besides their direct anti-tumor activities, probiotics can be used as an additional agent for enhancing or modulating other diagnostic and therapeutic methods. Herein, the effects of probiotics on cervical cancer cells are discussed, which may be useful in the prevention and treatment of this cancer. We review the studies concerned with the roles of probiotics in modulating and reducing the gastrointestinal adverse effects caused by cervical cancer therapies. Furthermore, we cover the investigations focusing on the combination of probiotics with other drugs for diagnosis or treatment of cervical cancer.

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“…Allegra and colleagues alluded to an interaction between miRNAs and the microbiome (Allegra et al 2020 ). Treatment of ovarian cancer cells with Lactobacillus lactis , a vaginal synbiont, modulates the expression of miR-21 and miR-200b, and, subsequently, TLR4 responsiveness of CAOV-4 cells (Rahbar Saadat 2019 ). The activation of TLR2, 4, and 5 culminate in the activation of inflammation-associated cytokine signaling pathways in ovarian cancer and the adjacent tissues, leading to the activation of NF-kappa B signaling (Zhou 2019a ).…”

Section: Oncobiotic Transformation In Ovarian Cancermentioning

confidence: 99%

The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling

Sipos

Ujlaki

Mikó

et al. 2021

Mol Med

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Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic diseases. In ovarian cancer, oncobiosis was identified in numerous compartments, including the tumor tissue itself, the upper and lower female genital tract, serum, peritoneum, and the intestines. Colonization was linked to Gram-negative bacteria with high inflammatory potential. Local inflammation probably participates in the initiation and continuation of carcinogenesis. Furthermore, local bacterial colonies in the peritoneum may facilitate metastasis formation in ovarian cancer. Vaginal infections (e.g. Neisseria gonorrhoeae or Chlamydia trachomatis) increase the risk of developing ovarian cancer. Bacterial metabolites, produced by the healthy eubiome or the oncobiome, may exert autocrine, paracrine, and hormone-like effects, as was evidenced in breast cancer or pancreas adenocarcinoma. We discuss the possible involvement of lipopolysaccharides, lysophosphatides and tryptophan metabolites, as well as, short-chain fatty acids, secondary bile acids and polyamines in the carcinogenesis of ovarian cancer. We discuss the applicability of nutrients, antibiotics, and probiotics to harness the microbiome and support ovarian cancer therapy. The oncobiome and the most likely bacterial metabolites play vital roles in mediating the effectiveness of chemotherapy. Finally, we discuss the potential of oncobiotic changes as biomarkers for the diagnosis of ovarian cancer and microbial metabolites as possible adjuvant agents in therapy.

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Modulatory Role of Vaginal-Isolated Lactococcus lactis on the Expression of miR-21, miR-200b, and TLR-4 in CAOV-4 Cells and In Silico Revalidation

Cited by 19 publications

References 47 publications

Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities

Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities

Anti-tumor activities of probiotics in cervical cancer

The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling

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