Modulatory role of serotonin on feeding behavior

Magalhães, Carolina Peixoto; Freitas, Manuela Figueiroa Lyra de; Nogueira, Maria Inês; Campina, Renata Cristinny de Farias; Takase, Luiz Fernando; Souza, Sandra Lopes de; Castro, Raul Manhães de

doi:10.1179/147683010x12611460764723

Cited by 28 publications

(14 citation statements)

References 132 publications

(148 reference statements)

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“…Plasma Trp : LNAA ratio has been shown to be a major determinant of brain 5-HT concentration (Fernstrom and Wurtman, 1972), which has been reported to be involved in the regulation of feeding behaviour (Magalhaes et al, 2010). For instance, it has been demonstrated that food-seeking and food-taking behaviours are usually reduced in non-human primates with increased brain 5-HT turnover (Foltin, 2001).…”

Section: Discussionmentioning

confidence: 99%

Effects of resistant starch on behaviour, satiety-related hormones and metabolites in growing pigs

Silva

Haenen

Koopmans

et al. 2014

Animal

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Resistant starch (RS) has been suggested to prolong satiety in adult pigs. The present study investigated RS-induced changes in behaviour, satiety-related hormones and metabolites in catheterized growing pigs to explore possible underlying mechanisms for RS-induced satiety. In a cross-over design with two 14-day periods, 10 pigs (initial BW: 58 kg) were assigned to two treatments comprising diets containing either 35% pregelatinized starch (PS) or 34% retrograded starch (RS). Diets were isoenergetic on gross energy. Pigs were fed at 2.8 × maintenance. Postprandial plasma response of satiety-related hormones and metabolites was measured at the end of each period using frequent blood sampling. Faecal and urinary energy losses were measured at the end of each period. Behaviour was scored 24 h from video recordings using scan sampling. Energy digestibility and metabolizability werẽ 6% lower in RS compared with PS diet ( P < 0.001), and metabolizable energy (ME) intake was~3% lower in RS-fed than in PS-fed pigs ( P < 0.001). RS-fed pigs showed less feeder-directed ( P = 0.001) and drinking ( P = 0.10) behaviours than PS-fed pigs throughout the day. Postprandial peripheral short-chain fatty acid (SCFA) levels were higher in RS-fed than in PS-fed pigs ( P < 0.001). Postprandial glucose and insulin responses were lower in RS-fed than in PS-fed pigs ( P < 0.001). Triglyceride levels were higher in RS-fed than in PS-fed pigs ( P < 0.01), and non-esterified fatty acid levels did not differ between diets ( P = 0.90). Glucagon-like peptide-1 (GLP-1) levels were lower in RS-fed than in PS-fed pigs ( P < 0.001), and peptide tyrosine tyrosine (PYY) levels did not differ between diets ( P = 0.90). Blood serotonin levels were lower ( P < 0.001), whereas monoamine oxidase activity ( P < 0.05) and tryptophan ( P < 0.01) levels were higher in RS-fed than in PS-fed pigs. Despite a lower ME intake, RS seemed to prolong satiety, based on behavioural observations. Possible underlying mechanisms for RS-induced satiety include increased 24 h plasma SCFA levels, and decreased postprandial glucose and insulin responses. GLP-1 and PYY seemed not to play a role in RS-induced satiety. Low blood serotonin levels in RS-fed pigs suggested a difference in intestinal serotonin release between treatments. Increased postprandial plasma triglyceride levels corresponded with increased SCFA levels, but it is unclear whether triglycerides may have signalled satiety in RS-fed pigs.

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Section: Discussionmentioning

confidence: 99%

Effects of resistant starch on behaviour, satiety-related hormones and metabolites in growing pigs

Silva

Haenen

Koopmans

et al. 2014

Animal

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“…Some worm strains exhibit social feeding, which involves avoidance of noxious chemical stimuli in a process requiring the TRP channels, OCR-2 and OSM-9 (de Bono et al 2002). Additionally, OCR-2 impacts on the biosynthesis of serotonin (Sokolchik et al 2005; Zhang et al 2004)—a neurotransmitter with conserved roles in regulating feeding behavior (Magalhaes et al 2010; Neckameyer 2010; Sze et al 2000). OCR-2 also functions in a small subset of peripheral sensory neurons in C. elegans larvae that mediate the detection of nutrient availability and neuropeptide release (Lee and Ashrafi 2008).…”

Section: Sensory Transductionmentioning

confidence: 99%

Evolutionarily Conserved, Multitasking TRP Channels: Lessons from Worms and Flies

Venkatachalam¹,

Luo

Montell

2014

Handbook of Experimental Pharmacology

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The Transient Receptor Potential (TRP) channel family is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling. TRPs allow animals to detect chemicals, mechanical force, light, and changes in temperature. Consequently, these channels control a plethora of animal behaviors. Moreover, their functions are not limited to the classical senses, as they are cellular sensors, which are critical for ionic homeostasis and metabolism. Two genetically tractable invertebrate model organisms, Caenorhabditis elegans and Drosophila melanogaster, have led the way in revealing a wide array of sensory roles and behaviors that depend on TRP channels. Two overriding themes have emerged from these studies. First, TRPs are multitasking proteins, and second, many functions and modes of activation of these channels are evolutionarily conserved, including some that were formerly thought to be unique to invertebrates, such as phototransduction. Thus, worms and flies offer the potential to decipher roles for mammalian TRPs, which would otherwise not be suspected.

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“…Variations in genes related to serotonin availability and its mechanism of action might influence food intake behavior, increasing the susceptibility of some individuals to obesity [5,6]. Among these genes, the solute carrier family 6 member 14 (SLC6A14) gene plays a key role in the bioavailability of this neurotransmitter because it regulates the availability of tryptophan for serotonin synthesis and thus can affect the control of appetite and mood [7].…”

Section: Introductionmentioning

confidence: 99%

SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children

Miranda

Vetter

Genro

et al. 2015

Clinical Biochemistry

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Modulatory role of serotonin on feeding behavior

Cited by 28 publications

References 132 publications

Effects of resistant starch on behaviour, satiety-related hormones and metabolites in growing pigs

Effects of resistant starch on behaviour, satiety-related hormones and metabolites in growing pigs

Evolutionarily Conserved, Multitasking TRP Channels: Lessons from Worms and Flies

SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children

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