Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-Induced Oxidative Stress in Wistar Albinos Rats

Abstract

Bisphenol A, an everywhere chemical, is applied as a plasticizer in polycarbonate plastics, which often used in our everyday products and in epoxy resins as protective coatings and linings for food and beverage cans for decades. Human exposure to BPA may lead to adverse effects by interfering with oestrogen receptors. Our present study was conducted to investigate the protective effects of selenium (Se) and vitamin E (Vit E) on BPA-induced damage in the liver of male rats. Animals were randomly divided into four groups: the first group received olive oil and served as control. The second group received both (Se + Vit E) (0.5 mg/kg diet; 100 mg/kg of diet). The third one treated orally by (10 mg/kg b.w.) of BPA. The last group received (Se + Vit E) (0.5 mg/kg diet; 100 mg/kg of diet) concomitantly with (10 mg/kg b.w.) BPA. Exposure to BPA for three weeks engendered a hepatic disorder. An increased AST and ALT enzymatic activity was noticed in BPA-treated group as compared to other groups. Furthermore, a change in glucose, cholesterol, LDL-C, HDL-C, albumin, and bilirubin level was remarkable. Moreover, exposure to BPA increased malondialdehyde levels while reduced gluthatione content was decreased in the liver homogenate. A decrease in glutathione peroxidase, glutathione s-transferase and catalase activities was observed in the same group. Administration of selenium and vitamin E through the diet in BPA treated rats ameliorated the biochemical parameters cited above. In addition, an improvement in activities of liver enzymes was recorded. The histological findings confirmed the biochemical results. The model of this study that we employed characterized the relationships between BPA-induced hepatotoxicity and its alleviation by natural antioxidants like selenium and vitamin E.

Role of Antioxidants in Alleviating Bisphenol A Toxicity

“…In another study, while 3-week exposure of male rats to BPA increased the body weight whereas vitamin E treatment reduced the body weight than that of BPA-treated and control groups. BPA causes potentiated hepatic damage, co-administering vitamin E protected the cells from major biochemical alternations [105]. This included decrease in GSH peroxidase, GSH S-transferase, and CAT activities, and changes in glucose, cholesterol, albumin, and bilirubin levels.…”

Antioxidant activity of novel selena-diazole derivative against oxidative stress induced by dipyrone in female rats

“…Furthermore (Hasanvand et al, 2017) showed that administration of Se remarkably decreased MDA. Recent study (Amraoui et al, 2018) has reported that rats treated concomitantly with bisphenol A (BPA) and (Se + Vit E) displayed a significant decrease in MDA concentration as compared to BPA-treated group. Selenium could reduce the elevated MDA level by about 5-fold compared to the diabetic rats (Ghaffari et al, 2011).…”

Bisphenol-A Dose-dependently Regulates The Development of Ovary and Uterus through Differential Expression of METTL3

“…The bound free BPA can be metabolized by glucuronic acid or sulfonic acid in the liver and excreted via the kidney [10]. Fetal or perinatal BPA exposure can affect the brain [11], heart [12], liver [13], kidney [14], adipose tissue, breast [15] and the reproductive system [16,17] at lower relative concentrations, resulting in, for example, obesity, diabetes [18], PCOS [19]. Furthermore, substantial BPA-induced reproductive toxicity has been observed.…”