Modulatory Role of Mucuna Pruriens against Aluminium Fluoride Induced Neuronal and Behavioural Alterations in Rats

Nayak, Vanishri S.; Kumar, Nitesh; D’Souza, Antony Sylvan; Nayak, Sunil S; Pai, K. S. R.

doi:10.7860/jcdr/2018/31529.11424

Cited by 1 publication

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“…Following training, On day zero, these rats were exposed to the same environmental condition for 300 s on the rotating rod with increasing rpm of 4–40 rpm, and the latency time was recorded. The event period of 300s is the duration during which the animals are measured for latency to maintain balance on the rotarod [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

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Effect of Moringa oleifera leaf extract on exercise and dexamethasone-induced functional impairment in skeletal muscles

Barodia

Cheruku

Kanwal

et al. 2022

Journal of Ayurveda and Integrative Medicine

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Background Chronic administration of steroids like dexamethasone produces symptoms including weight loss and skeletal muscle dysfunction. Similar events are reported in chronic or high-intensity exercises, that can lead to fatigue and muscle damage. Objective In the present study, the effect of Moringa oleifera leaf extract was evaluated against dexamethasone (Dex) and exercise (Exe)-induced muscle changes in rats. Materials and methods Six groups each containing 6 rats, namely normal, Dex control, Exe Control, Dex + M. oleifera leaf extract (300mg/kg p.o. ), Dex + Exe, Dex + Exe + M. oleifera leaf extract were assessed in the study. Dex was administered at 0.6 mg/kg i.p. daily for 7 days. Exercise was given for a total of 10 days after 30 minutes of dosing using treadmill equipment for 900 seconds at speed 18 m/min. Animals were assessed for variation in body weight, muscular endurance using treadmill, locomotor activity using actophotometer, motor coordination using rotarod on day zero, and day seven. Hemidiaphragm of rats were isolated and used for evaluation of the glucose uptake. Gastrocnemius muscle was isolated and subjected to hematoxylin and eosin staining. Results Dex and Exe control animals showed a significant decrease in skeletal muscle activity when compared to normal control animals in the actophotometer test. Improvement in endurance were seen in Dex + M. oleifera leaf extract, and Dex + exercise + M. oleifera leaf extract groups compared to Dex control group. Improvement in locomotor activity was seen in Dex group subjected to exercise and was significant when treated with M. oleifera leaf extract. Histology reports were in accordance with the functional parameters. Conclusion M. oleifera leaf extract supplemented with exercise showed a reversal in the dexamethasone-induced functional impairment in skeletal muscles.

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Section: Methodsmentioning

confidence: 99%

“…Animals were placed individually in the activity meter, for them to get acclimatized to the environment before performing the test. For the next 5 min, the ambulatory movements were recorded and expressed in terms of total photobeam count [ 17 ].…”

Section: Methodsmentioning

confidence: 99%