Modulatory effects of the acid polysaccharide fraction from one of anamorph of Cordyceps sinensis on Ana-1 cells

Chen, Weixia; Yuan, Fengjiao; Wang, Kongcheng; Song, Dandan; Zhang, Weiyun

doi:10.1016/j.jep.2012.05.055

Cited by 26 publications

(10 citation statements)

References 30 publications

(35 reference statements)

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“…Similarly another study reported that CS could augment the NK cell activity and improves the CD16 marker expression on lymphocytes and the binding capacity to K562 cells (Liu et al, 1992). Further, acid polysaccharide fraction (APSF), from an anamorph of CS has stimulating activity on macrophages where increased expressions of TNF-a, IL-12 and iNOS, and reduced the expression of IL-10 of Ana-1 cells were observed (Chen, Yuan, Wang, Song, & Zhang, 2012). On the other hand CS extract was found to enhance the MHC class II antigen expression on HA22T/VGH cells of human hepatoma cell line HA22T/VGH.…”

Section: Immunomodulatory Effectsmentioning

confidence: 97%

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Shashidhar

Giridhar

Sankar

et al. 2013

Journal of Functional Foods

100

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Extraction Health benefits A B S T R A C T Cordyceps sinensis (CS) is a well-known entamophagus fungus, naturally distributed in the Tibetan Plateau of Asia and Himalayas. Recently this synonym is transferred to Ophiocordyceps by both scientific and non-scientific communities. It is widely used as a tonic and medicinal food in traditional Chinese medicine (TCM), as it possess wonderful health benefits. To support its functional attributes, various investigations have been carried out to find out its adaptogenic, aphrodisiac, anti-oxidant, anti-aging, neuroprotective, nootropic, immunomodulatory, anti-cancer and hepatoprotective role. Its fruiting portion as well as the larvae possesses potent bio-active fractions and their composition almost found to be similar in both. The bioactive principles are nucleosides, exo-polysaccharides, sterols and, proteins, among others. Among nucleosides, adenosine and cordycepin are the major biochemical markers. Further, different types of solvent extracts and their mixtures exhibit wide range of pharmacological activities, while the water and methanol extracts with the richest sources of nucleosides and polysaccharides also show wide range of pharmacological activities. This review gives a panoramic view of potential health benefits of various classes of bio-active fractions along with the need for sustainable management of CS for human wellness.

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Section: Immunomodulatory Effectsmentioning

confidence: 97%

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Shashidhar

Giridhar

Sankar

et al. 2013

Journal of Functional Foods

100

View full text Add to dashboard Cite

show abstract

“…linkage are some of the structural features recognized to contribute to the polysaccharides immunostimulatory activity [34]. The content of uronic acids has been considered to play important roles in biological activity [35][36][37], and many acid polysaccharides have immunomodulatory activity [36][37][38]. The existence of functional groups of monosaccharides is a crucial structural feature for immunostimulatory activity [36,37].…”

Section: Immunological Activity and Structurementioning

confidence: 99%

Structure elucidation of a pectin fromDendrobium nobileLindl. and its immunological activity

Wang

Zhang

Luo

2018

Biotechnology & Biotechnological Equipment

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In this study, an RG-I pectin DNP-W6 was isolated from the stems of Dendrobium nobile Lindl. (Orchidaceae). It contained mannose, glucose, galactose, galacturonic acid and rhamnose in a molar ratio of 0.6: 1.0: 1.5: 1.1: 1.0. Its structural features were revealed by chemical, physical and spectral analysis. The results suggested that DNP-W6 possessed a backbone of a disaccharide of !4)-a-GalAp-(1!2)-a-Rhap-(1!, with approximate 50% substitution at O-4 of the rhamnopyranosyl residues. The side chains were neutral chains including galactosyl, mannosyl and glucosyl chains. The acetyl content was estimated to be 8.9%. The immunological results indicated that DNP-W6 and its derivatives exhibited different immunological activities in vitro, showing that the side chains and acetyl groups had an important effect on the expression of immunological activities.

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“…CPS activated the mitogen–activated protein kinase (MAPK) and nuclear factor‐κB (NF‐κB) signaling pathways through several pattern recognition receptors (PRRs) such as Toll‐like receptor (TLR)‐2, TLR‐4, and Detin‐1, upregulated the expression of proinflammatory mediators tumor necrosis factor‐α (TNF‐α), IL‐1β, and IL‐12, and promoted respiratory burst activity and nitric oxide (NO) production, leading to the conversion of the macrophage phenotype from M2 to M1 and enhancing phagocytosis in mouse macrophage cell lines (Chen, Yuan, Wang, Song, & Zhang, ; Lee et al, ; Zhu et al, ). CPS enhanced spleen lymphocyte proliferation and activity in immunosuppressed or tumor‐bearing mice (Zhang, Yang, Chen, Hou, & Han, , Wang, Meng, et al, ).…”

Section: Main Components and Derivatives Of Cordycepsmentioning

confidence: 99%

The potential application of Cordyceps in metabolic‐related disorders

Cao

Yang

Zhou

2019

Phytotherapy Research

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Changes in the global economy resulted in sedentary lifestyle and excessive calorie intake, increasing the incidence of metabolic diseases, which subsequently became a universal public concern. The difficulties of managing chronic diseases did not dampen researchers' enthusiasm for studying new therapeutics or adjuvant treatments. Cordyceps spp. is a kind of traditional Chinese herbal medicine; however, our understanding of this medicine remains at an initial stage. Recently, an increasing number of studies have demonstrated the potential of Cordyceps as a therapeutic agent for the effective treatment of metabolic-related disorders by exerting a variety of activities, including but not limited to anti-inflammatory, immunoregulatory, hypoglycemic, renoprotective and cardiovascular-protective effects. This article reviews the potential efficacy and underlying mechanisms of Cordyceps and its major bioactive ingredients in metabolic syndrome and its associated comorbidities.

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Modulatory effects of the acid polysaccharide fraction from one of anamorph of Cordyceps sinensis on Ana-1 cells

Cited by 26 publications

References 30 publications

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Structure elucidation of a pectin fromDendrobium nobileLindl. and its immunological activity

The potential application of Cordyceps in metabolic‐related disorders

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